Guarente L - Search Results

1

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M. Liu Y, et al. Among authors: guarente l. Nature. 2008 Nov 13;456(7219):269-73. doi: 10.1038/nature07349. Epub 2008 Oct 5. Nature. 2008. PMID: 18849969 Free PMC article.

2

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR 3rd, Bordone L, Guarente L, Krainc D. Jeong H, et al. Among authors: guarente l. Nat Med. 2011 Dec 18;18(1):159-65. doi: 10.1038/nm.2559. Nat Med. 2011. PMID: 22179316 Free PMC article.

3

SIR2: a potential target for calorie restriction mimetics.

Chen D, Guarente L. Chen D, et al. Among authors: guarente l. Trends Mol Med. 2007 Feb;13(2):64-71. doi: 10.1016/j.molmed.2006.12.004. Epub 2007 Jan 4. Trends Mol Med. 2007. PMID: 17207661 Review.

4

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.

Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P. Nakahata Y, et al. Cell. 2008 Jul 25;134(2):329-40. doi: 10.1016/j.cell.2008.07.002. Cell. 2008. PMID: 18662547 Free PMC article.

5

Increase in activity during calorie restriction requires Sirt1.

Chen D, Steele AD, Lindquist S, Guarente L. Chen D, et al. Among authors: guarente l. Science. 2005 Dec 9;310(5754):1641. doi: 10.1126/science.1118357. Science. 2005. PMID: 16339438

6

Tissue-specific regulation of SIRT1 by calorie restriction.

Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Chen D, et al. Among authors: guarente l. Genes Dev. 2008 Jul 1;22(13):1753-7. doi: 10.1101/gad.1650608. Epub 2008 Jun 11. Genes Dev. 2008. PMID: 18550784 Free PMC article.

7

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.

Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. Picard F, et al. Among authors: guarente l. Nature. 2004 Jun 17;429(6993):771-6. doi: 10.1038/nature02583. Epub 2004 Jun 2. Nature. 2004. PMID: 15175761 Free PMC article.

8

The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.

Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L. Chen D, et al. Among authors: guarente l. Exp Gerontol. 2008 Dec;43(12):1086-93. doi: 10.1016/j.exger.2008.08.050. Epub 2008 Aug 30. Exp Gerontol. 2008. PMID: 18799131 Free PMC article.

9

Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI.

Kim KS, Guarente L. Kim KS, et al. Among authors: guarente l. Nature. 1989 Nov 9;342(6246):200-3. doi: 10.1038/342200a0. Nature. 1989. PMID: 2509943

10

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.

Tissenbaum HA, Guarente L. Tissenbaum HA, et al. Among authors: guarente l. Nature. 2001 Mar 8;410(6825):227-30. doi: 10.1038/35065638. Nature. 2001. PMID: 11242085

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