de Vries H - Search Results

1

2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.

Mantri M, de Graaf O, van Veldhoven J, Göblyös A, von Frijtag Drabbe Künzel JK, Mulder-Krieger T, Link R, de Vries H, Beukers MW, Brussee J, Ijzerman AP. Mantri M, et al. Among authors: de vries h, de graaf o. J Med Chem. 2008 Aug 14;51(15):4449-55. doi: 10.1021/jm701594y. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637670

2

Synthesis and biological evaluation of a new series of 2,3,5-substituted [1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action.

Göblyös A, de Vries H, Brussee J, Ijzerman AP. Göblyös A, et al. Among authors: de vries h. J Med Chem. 2005 Feb 24;48(4):1145-51. doi: 10.1021/jm049337s. J Med Chem. 2005. PMID: 15715480

3

A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor.

Heitman LH, Göblyös A, Zweemer AM, Bakker R, Mulder-Krieger T, van Veldhoven JP, de Vries H, Brussee J, Ijzerman AP. Heitman LH, et al. Among authors: de vries h. J Med Chem. 2009 Feb 26;52(4):926-31. doi: 10.1021/jm8014052. J Med Chem. 2009. PMID: 19161279

4

Substituted terphenyl compounds as the first class of low molecular weight allosteric inhibitors of the luteinizing hormone receptor.

Heitman LH, Narlawar R, de Vries H, Willemsen MN, Wolfram D, Brussee J, Ijzerman AP. Heitman LH, et al. Among authors: de vries h. J Med Chem. 2009 Apr 9;52(7):2036-42. doi: 10.1021/jm801561h. J Med Chem. 2009. PMID: 19296599

5

Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data.

van Westen GJ, van den Hoven OO, van der Pijl R, Mulder-Krieger T, de Vries H, Wegner JK, Ijzerman AP, van Vlijmen HW, Bender A. van Westen GJ, et al. Among authors: de vries h. J Med Chem. 2012 Aug 23;55(16):7010-20. doi: 10.1021/jm3003069. Epub 2012 Aug 3. J Med Chem. 2012. PMID: 22827545

6

Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists.

Vilums M, Zweemer AJ, Yu Z, de Vries H, Hillger JM, Wapenaar H, Bollen IA, Barmare F, Gross R, Clemens J, Krenitsky P, Brussee J, Stamos D, Saunders J, Heitman LH, Ijzerman AP. Vilums M, et al. Among authors: de vries h. J Med Chem. 2013 Oct 10;56(19):7706-14. doi: 10.1021/jm4011737. Epub 2013 Sep 27. J Med Chem. 2013. PMID: 24028535

7

Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.

Louvel J, Guo D, Agliardi M, Mocking TA, Kars R, Pham TP, Xia L, de Vries H, Brussee J, Heitman LH, Ijzerman AP. Louvel J, et al. Among authors: de vries h. J Med Chem. 2014 Apr 24;57(8):3213-22. doi: 10.1021/jm401643m. Epub 2014 Apr 3. J Med Chem. 2014. PMID: 24669958

8

When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists.

Vilums M, Zweemer AJ, Barmare F, van der Gracht AM, Bleeker DC, Yu Z, de Vries H, Gross R, Clemens J, Krenitsky P, Brussee J, Stamos D, Saunders J, Heitman LH, IJzerman AP. Vilums M, et al. Among authors: de vries h. Eur J Med Chem. 2015 Mar 26;93:121-34. doi: 10.1016/j.ejmech.2015.01.063. Epub 2015 Feb 2. Eur J Med Chem. 2015. PMID: 25666912

9

Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A₁ receptor antagonists.

Alachouzos G, Lenselink EB, Mulder-Krieger T, de Vries H, IJzerman AP, Louvel J. Alachouzos G, et al. Among authors: de vries h. Eur J Med Chem. 2017 Jan 5;125:586-602. doi: 10.1016/j.ejmech.2016.09.081. Epub 2016 Sep 26. Eur J Med Chem. 2017. PMID: 27718474

10

Design and synthesis of novel small molecule CCR2 antagonists: evaluation of 4-aminopiperidine derivatives.

Vilums M, Zweemer AJ, Dekkers S, Askar Y, de Vries H, Saunders J, Stamos D, Brussee J, Heitman LH, IJzerman AP. Vilums M, et al. Among authors: de vries h. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5377-80. doi: 10.1016/j.bmcl.2014.10.060. Bioorg Med Chem Lett. 2014. PMID: 25453791

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