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The largest prospective warfarin-treated cohort supports genetic forecasting.
Wadelius M, Chen LY, Lindh JD, Eriksson N, Ghori MJ, Bumpstead S, Holm L, McGinnis R, Rane A, Deloukas P. Wadelius M, et al. Among authors: holm l. Blood. 2009 Jan 22;113(4):784-92. doi: 10.1182/blood-2008-04-149070. Epub 2008 Jun 23. Blood. 2009. PMID: 18574025 Free PMC article.
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.
Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, Soranzo N, Whittaker P, Ranganath V, Kumanduri V, McLaren W, Holm L, Lindh J, Rane A, Wadelius M, Deloukas P. Takeuchi F, et al. Among authors: holm l. PLoS Genet. 2009 Mar;5(3):e1000433. doi: 10.1371/journal.pgen.1000433. Epub 2009 Mar 20. PLoS Genet. 2009. PMID: 19300499 Free PMC article.
Noscapine may increase the effect of warfarin.
Ohlsson S, Holm L, Myrberg O, Sundström A, Yue QY. Ohlsson S, et al. Among authors: holm l. Br J Clin Pharmacol. 2008 Feb;65(2):277-8. doi: 10.1111/j.1365-2125.2007.03018.x. Epub 2007 Sep 13. Br J Clin Pharmacol. 2008. PMID: 17875192 Free PMC article. Review. No abstract available.
992 results