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Page 1
Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis.
Rustomjee R, Diacon AH, Allen J, Venter A, Reddy C, Patientia RF, Mthiyane TC, De Marez T, van Heeswijk R, Kerstens R, Koul A, De Beule K, Donald PR, McNeeley DF. Rustomjee R, et al. Among authors: de beule k. Antimicrob Agents Chemother. 2008 Aug;52(8):2831-5. doi: 10.1128/AAC.01204-07. Epub 2008 May 27. Antimicrob Agents Chemother. 2008. PMID: 18505852 Free PMC article. Clinical Trial.
The diarylquinoline TMC207 for multidrug-resistant tuberculosis.
Diacon AH, Pym A, Grobusch M, Patientia R, Rustomjee R, Page-Shipp L, Pistorius C, Krause R, Bogoshi M, Churchyard G, Venter A, Allen J, Palomino JC, De Marez T, van Heeswijk RP, Lounis N, Meyvisch P, Verbeeck J, Parys W, de Beule K, Andries K, Mc Neeley DF. Diacon AH, et al. Among authors: de beule k. N Engl J Med. 2009 Jun 4;360(23):2397-405. doi: 10.1056/NEJMoa0808427. N Engl J Med. 2009. PMID: 19494215 Free article. Clinical Trial.
Pharmacokinetics and safety of a 7-day administration of intravenous itraconazole followed by a 14-day administration of itraconazole oral solution in patients with hematologic malignancy.
Boogaerts MA, Maertens J, Van Der Geest R, Bosly A, Michaux JM, Van Hoof A, Cleeren M, Wostenborghs R, De Beule K. Boogaerts MA, et al. Among authors: de beule k. Antimicrob Agents Chemother. 2001 Mar;45(3):981-5. doi: 10.1128/AAC.45.3.981-985.2001. Antimicrob Agents Chemother. 2001. PMID: 11181397 Free PMC article. Clinical Trial.
Itraconazole pharmacokinetics in patients with renal dysfunction.
Boelaert J, Schurgers M, Matthys E, Daneels R, van Peer A, De Beule K, Woestenborghs R, Heykants J. Boelaert J, et al. Among authors: de beule k. Antimicrob Agents Chemother. 1988 Oct;32(10):1595-7. doi: 10.1128/AAC.32.10.1595. Antimicrob Agents Chemother. 1988. PMID: 2847635 Free PMC article.
Concentrations in plasma and safety of 7 days of intravenous itraconazole followed by 2 weeks of oral itraconazole solution in patients in intensive care units.
Vandewoude K, Vogelaers D, Decruyenaere J, Jaqmin P, De Beule K, Van Peer A, Woestenborghs R, Groen K, Colardyn F. Vandewoude K, et al. Among authors: de beule k. Antimicrob Agents Chemother. 1997 Dec;41(12):2714-8. doi: 10.1128/AAC.41.12.2714. Antimicrob Agents Chemother. 1997. PMID: 9420044 Free PMC article. Clinical Trial.
Itraconazole oral solution for primary prophylaxis of fungal infections in patients with hematological malignancy and profound neutropenia: a randomized, double-blind, double-placebo, multicenter trial comparing itraconazole and amphotericin B.
Harousseau JL, Dekker AW, Stamatoullas-Bastard A, Fassas A, Linkesch W, Gouveia J, De Bock R, Rovira M, Seifert WF, Joosen H, Peeters M, De Beule K. Harousseau JL, et al. Among authors: de beule k, de bock r. Antimicrob Agents Chemother. 2000 Jul;44(7):1887-93. doi: 10.1128/AAC.44.7.1887-1893.2000. Antimicrob Agents Chemother. 2000. PMID: 10858349 Free PMC article. Clinical Trial.
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