Jurcevic S - Search Results

1

Two single-center, double-blind, randomized, placebo-controlled, phase I studies to investigate the tolerability and pharmacokinetics of CH-1504, an antifolate, in healthy male subjects.

Mant T, Jurcevic S, Szakacs C, Adams L, Boland J, Hewitt LA. Mant T, et al. Among authors: jurcevic s. Clin Ther. 2008 Jan;30(1):131-42. doi: 10.1016/j.clinthera.2008.01.017. Clin Ther. 2008. PMID: 18343249 Clinical Trial.

2

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers.

Coffey G, Rani A, Betz A, Pak Y, Haberstock-Debic H, Pandey A, Hollenbach S, Gretler DD, Mant T, Jurcevic S, Sinha U. Coffey G, et al. Among authors: jurcevic s. J Clin Pharmacol. 2017 Feb;57(2):194-210. doi: 10.1002/jcph.794. Epub 2016 Aug 17. J Clin Pharmacol. 2017. PMID: 27406873 Free PMC article.

3

Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers.

Borozdenkova S, Mant TG, Allen E, Pu K, Hoshino S, Jurcevic S. Borozdenkova S, et al. Among authors: jurcevic s. Int Immunopharmacol. 2011 Nov;11(11):1837-43. doi: 10.1016/j.intimp.2011.07.013. Epub 2011 Aug 3. Int Immunopharmacol. 2011. PMID: 21820084 Clinical Trial.

4

The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge.

Nicholson GC, Kariyawasam HH, Tan AJ, Hohlfeld JM, Quinn D, Walker C, Rodman D, Westwick J, Jurcevic S, Kon OM, Barnes PJ, Krug N, Hansel TT. Nicholson GC, et al. Among authors: jurcevic s. J Allergy Clin Immunol. 2011 Oct;128(4):800-807.e9. doi: 10.1016/j.jaci.2011.05.013. Epub 2011 Jun 29. J Allergy Clin Immunol. 2011. PMID: 21719078 Clinical Trial.

5

Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers.

Mant TG, Borozdenkova S, Bradford DB, Allen E, Amin DM, Toothaker RD, Collins RW, Hargreaves RE, Jurcevic S. Mant TG, et al. Among authors: jurcevic s. Int Immunopharmacol. 2008 May;8(5):701-7. doi: 10.1016/j.intimp.2008.01.014. Epub 2008 Feb 11. Int Immunopharmacol. 2008. PMID: 18387512

6

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions.

Jurcevic S, Humfrey C, Uddin M, Warrington S, Larsson B, Keen C. Jurcevic S, et al. Br J Clin Pharmacol. 2015 Dec;80(6):1324-36. doi: 10.1111/bcp.12724. Epub 2015 Oct 2. Br J Clin Pharmacol. 2015. PMID: 26182832 Free PMC article. Clinical Trial.

7

Effects of multiple-dose ponesimod, a selective S1P₁ receptor modulator, on lymphocyte subsets in healthy humans.

Jurcevic S, Juif PE, Hamid C, Greenlaw R, D'Ambrosio D, Dingemanse J. Jurcevic S, et al. Drug Des Devel Ther. 2016 Dec 28;11:123-131. doi: 10.2147/DDDT.S120399. eCollection 2017. Drug Des Devel Ther. 2016. PMID: 28096659 Free PMC article. Clinical Trial.

8

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation.

Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K, Herlaar E, Lau A, Young C, Wong BR, Lovell S, Sun T, Park G, Argade A, Jurcevic S, Pine P, Singh R, Grossbard EB, Payan DG, Masuda ES. Braselmann S, et al. Among authors: jurcevic s. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. doi: 10.1124/jpet.106.109058. Epub 2006 Aug 31. J Pharmacol Exp Ther. 2006. PMID: 16946104 Clinical Trial.

9

FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells.

Rani A, Greenlaw R, Runglall M, Jurcevic S, John S. Rani A, et al. Among authors: jurcevic s. PLoS One. 2014 Feb 28;9(2):e90370. doi: 10.1371/journal.pone.0090370. eCollection 2014. PLoS One. 2014. PMID: 24587342 Free PMC article.

10

A phase 1 study of prasugrel in patients with sickle cell disease: pharmacokinetics and effects on ex vivo platelet reactivity.

Jakubowski JA, Zhou C, Small DS, Winters KJ, Lachno DR, Frelinger AL 3rd, Howard J, Mant TG, Jurcevic S, Payne CD. Jakubowski JA, et al. Among authors: jurcevic s. Br J Clin Pharmacol. 2013 Jun;75(6):1433-44. doi: 10.1111/bcp.12042. Br J Clin Pharmacol. 2013. PMID: 23171128 Free PMC article. Clinical Trial.

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