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The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1).
Nittoli T, Dushin RG, Ingalls C, Cheung K, Floyd MB, Fraser H, Olland A, Hu Y, Grosu G, Han X, Arndt K, Guo B, Wissner A. Nittoli T, et al. Among authors: han x. Eur J Med Chem. 2010 Apr;45(4):1379-86. doi: 10.1016/j.ejmech.2009.12.036. Epub 2009 Dec 28. Eur J Med Chem. 2010. PMID: 20074837
AMPK promotes the survival of colorectal cancer stem cells.
Guo B, Han X, Tkach D, Huang SG, Zhang D. Guo B, et al. Among authors: han x. Animal Model Exp Med. 2018 Jul 28;1(2):134-142. doi: 10.1002/ame2.12016. eCollection 2018 Jun. Animal Model Exp Med. 2018. PMID: 30891558 Free PMC article.
Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Cornish K, Huo J, Jones L, Sharma P, Thrush JW, Abdelkarim S, Kipar A, Ramadurai S, Weckener M, Mikolajek H, Liu S, Buckle I, Bentley E, Kirby A, Han X, Laidlaw SM, Hill M, Eyssen L, Norman C, Le Bas A, Clarke J, James W, Stewart JP, Carroll M, Naismith JH, Owens RJ. Cornish K, et al. Among authors: han x. Open Biol. 2024 Jun;14(6):230252. doi: 10.1098/rsob.230252. Epub 2024 Jun 4. Open Biol. 2024. PMID: 38835241
Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations.
Shen M, Chen S, Han X, Hao Y, Wang J, Li L, Chen T, Wang B, Zou L, Zhang T, Zhang W, Han X, Wang W, Yu H, Li K, Liu S, Jin A. Shen M, et al. Among authors: han x. Cancer Immunol Immunother. 2024 Jun 4;73(8):150. doi: 10.1007/s00262-024-03729-y. Cancer Immunol Immunother. 2024. PMID: 38832948
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