Watterson DM - Search Results

1

Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.

Somera-Molina KC, Robin B, Somera CA, Anderson C, Stine C, Koh S, Behanna HA, Van Eldik LJ, Watterson DM, Wainwright MS. Somera-Molina KC, et al. Among authors: watterson dm. Epilepsia. 2007 Sep;48(9):1785-1800. doi: 10.1111/j.1528-1167.2007.01135.x. Epub 2007 May 23. Epilepsia. 2007. PMID: 17521344 Free article.

2

Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.

Somera-Molina KC, Nair S, Van Eldik LJ, Watterson DM, Wainwright MS. Somera-Molina KC, et al. Among authors: watterson dm. Brain Res. 2009 Jul 28;1282:162-72. doi: 10.1016/j.brainres.2009.05.073. Epub 2009 Jun 6. Brain Res. 2009. PMID: 19501063 Free PMC article.

3

Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo.

Craft JM, Watterson DM, Frautschy SA, Van Eldik LJ. Craft JM, et al. Among authors: watterson dm. Neurobiol Aging. 2004 Nov-Dec;25(10):1283-92. doi: 10.1016/j.neurobiolaging.2004.01.006. Neurobiol Aging. 2004. PMID: 15465624

4

Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.

Craft JM, Watterson DM, Marks A, Van Eldik LJ. Craft JM, et al. Among authors: watterson dm. Glia. 2005 Aug 15;51(3):209-16. doi: 10.1002/glia.20194. Glia. 2005. PMID: 15810011

5

Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration.

Craft JM, Watterson DM, Van Eldik LJ. Craft JM, et al. Among authors: watterson dm. Glia. 2006 Apr 1;53(5):484-90. doi: 10.1002/glia.20306. Glia. 2006. PMID: 16369931

6

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LJ, Watterson DM. Ralay Ranaivo H, et al. Among authors: watterson dm. J Neurosci. 2006 Jan 11;26(2):662-70. doi: 10.1523/JNEUROSCI.4652-05.2006. J Neurosci. 2006. PMID: 16407564 Free PMC article.

7

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.

Hu W, Ralay Ranaivo H, Roy SM, Behanna HA, Wing LK, Munoz L, Guo L, Van Eldik LJ, Watterson DM. Hu W, et al. Among authors: watterson dm. Bioorg Med Chem Lett. 2007 Jan 15;17(2):414-8. doi: 10.1016/j.bmcl.2006.10.028. Epub 2006 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17079143 Free PMC article.

8

A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ, Watterson DM. Munoz L, et al. Among authors: watterson dm. J Neuroinflammation. 2007 Sep 4;4:21. doi: 10.1186/1742-2094-4-21. J Neuroinflammation. 2007. PMID: 17784957 Free PMC article.

9

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.

Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS. Lloyd E, et al. Among authors: watterson dm. J Neuroinflammation. 2008 Jun 30;5:28. doi: 10.1186/1742-2094-5-28. J Neuroinflammation. 2008. PMID: 18590543 Free PMC article.

10

Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug.

Karpus WJ, Reynolds N, Behanna HA, Van Eldik LJ, Watterson DM. Karpus WJ, et al. Among authors: watterson dm. J Neuroimmunol. 2008 Oct 15;203(1):73-8. doi: 10.1016/j.jneuroim.2008.06.039. J Neuroimmunol. 2008. PMID: 18678415 Free PMC article.

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