O'Keefe RJ - Search Results

1

Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2.

Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. Wang Q, et al. J Biol Chem. 2007 Apr 6;282(14):10742-8. doi: 10.1074/jbc.M610997200. Epub 2007 Jan 10. J Biol Chem. 2007. PMID: 17215250 Free PMC article.

2

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.

Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D. Shen R, et al. J Biol Chem. 2006 Feb 10;281(6):3569-76. doi: 10.1074/jbc.M506761200. Epub 2005 Nov 18. J Biol Chem. 2006. PMID: 16299379 Free PMC article.

3

Cyclin D1-cdk4 induce runx2 ubiquitination and degradation.

Shen R, Wang X, Drissi H, Liu F, O'Keefe RJ, Chen D. Shen R, et al. J Biol Chem. 2006 Jun 16;281(24):16347-53. doi: 10.1074/jbc.M603439200. Epub 2006 Apr 13. J Biol Chem. 2006. PMID: 16613857 Free PMC article.

4

Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.

Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. Li TF, et al. J Biol Chem. 2006 Jul 28;281(30):21296-21304. doi: 10.1074/jbc.M600514200. Epub 2006 May 10. J Biol Chem. 2006. PMID: 16690606 Free PMC article.

5

Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2.

Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF. Usui M, et al. J Bone Miner Res. 2008 Mar;23(3):314-25. doi: 10.1359/jbmr.071025. J Bone Miner Res. 2008. PMID: 17967138 Free PMC article.

6

TGF-beta signaling in chondrocytes.

Li TF, O'Keefe RJ, Chen D. Li TF, et al. Front Biosci. 2005 Jan 1;10:681-8. doi: 10.2741/1563. Print 2005 Jan 1. Front Biosci. 2005. PMID: 15569609 Free PMC article. Review.

7

Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin.

Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN. Wu Q, et al. J Bone Miner Res. 2008 Apr;23(4):552-63. doi: 10.1359/jbmr.071115. J Bone Miner Res. 2008. PMID: 18052755 Free PMC article.

8

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D. Shu B, et al. J Cell Sci. 2011 Oct 15;124(Pt 20):3428-40. doi: 10.1242/jcs.083659. Epub 2011 Oct 7. J Cell Sci. 2011. PMID: 21984813 Free PMC article.

9

Regulation of embryonic endochondral ossification by Smurf2.

Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. Wu Q, et al. J Orthop Res. 2008 May;26(5):704-12. doi: 10.1002/jor.20563. J Orthop Res. 2008. PMID: 18176945 Free PMC article.

10

Beta-catenin, cartilage, and osteoarthritis.

Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D. Wu Q, et al. Ann N Y Acad Sci. 2010 Mar;1192(1):344-50. doi: 10.1111/j.1749-6632.2009.05212.x. Ann N Y Acad Sci. 2010. PMID: 20392258 Free PMC article. Review.

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