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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.
Neurobiol Dis. 2007 Feb;25(2):401-11. doi: 10.1016/j.nbd.2006.10.007. Epub 2006 Nov 30.
Neurobiol Dis. 2007.
PMID: 17141510
Parkinson patient fibroblasts show increased alpha-synuclein expression.
Hoepken HH, Gispert S, Azizov M, Klinkenberg M, Ricciardi F, Kurz A, Morales-Gordo B, Bonin M, Riess O, Gasser T, Kögel D, Steinmetz H, Auburger G.
Hoepken HH, et al.
Exp Neurol. 2008 Aug;212(2):307-13. doi: 10.1016/j.expneurol.2008.04.004. Epub 2008 Apr 16.
Exp Neurol. 2008.
PMID: 18511044
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Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.
Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D, Voos W, Leuner K, Müller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, García-Arencíbia M, Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G.
Gispert S, et al. Among authors: hoepken hh.
PLoS One. 2009 Jun 3;4(6):e5777. doi: 10.1371/journal.pone.0005777.
PLoS One. 2009.
PMID: 19492057
Free PMC article.
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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C.
Exner N, et al. Among authors: hoepken hh.
J Neurosci. 2007 Nov 7;27(45):12413-8. doi: 10.1523/JNEUROSCI.0719-07.2007.
J Neurosci. 2007.
PMID: 17989306
Free PMC article.
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Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.
Torres-Odio S, Key J, Hoepken HH, Canet-Pons J, Valek L, Roller B, Walter M, Morales-Gordo B, Meierhofer D, Harter PN, Mittelbronn M, Tegeder I, Gispert S, Auburger G.
Torres-Odio S, et al. Among authors: hoepken hh.
J Neuroinflammation. 2017 Aug 2;14(1):154. doi: 10.1186/s12974-017-0928-0.
J Neuroinflammation. 2017.
PMID: 28768533
Free PMC article.
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Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity.
Liddell JR, Hoepken HH, Crack PJ, Robinson SR, Dringen R.
Liddell JR, et al. Among authors: hoepken hh.
J Neurosci Res. 2006 Aug 15;84(3):578-86. doi: 10.1002/jnr.20957.
J Neurosci Res. 2006.
PMID: 16721761
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Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate.
Hoepken HH, Korten T, Robinson SR, Dringen R.
Hoepken HH, et al.
J Neurochem. 2004 Mar;88(5):1194-202. doi: 10.1046/j.1471-4159.2003.02236.x.
J Neurochem. 2004.
PMID: 15009675
Free article.
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Colorimetric ferrozine-based assay for the quantitation of iron in cultured cells.
Riemer J, Hoepken HH, Czerwinska H, Robinson SR, Dringen R.
Riemer J, et al. Among authors: hoepken hh.
Anal Biochem. 2004 Aug 15;331(2):370-5. doi: 10.1016/j.ab.2004.03.049.
Anal Biochem. 2004.
PMID: 15265744
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