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First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity.
Circulation. 2006 Dec 5;114(23):2490-7. doi: 10.1161/CIRCULATIONAHA.106.668434. Epub 2006 Nov 13.
Circulation. 2006.
PMID: 17101847
Clinical Trial.
Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease.
Chan MY, Cohen MG, Dyke CK, Myles SK, Aberle LG, Lin M, Walder J, Steinhubl SR, Gilchrist IC, Kleiman NS, Vorchheimer DA, Chronos N, Melloni C, Alexander JH, Harrington RA, Tonkens RM, Becker RC, Rusconi CP.
Chan MY, et al. Among authors: myles sk.
Circulation. 2008 Jun 3;117(22):2865-74. doi: 10.1161/CIRCULATIONAHA.107.745687. Epub 2008 May 27.
Circulation. 2008.
PMID: 18506005
Clinical Trial.
Item in Clipboard
First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention.
Cohen MG, Purdy DA, Rossi JS, Grinfeld LR, Myles SK, Aberle LH, Greenbaum AB, Fry E, Chan MY, Tonkens RM, Zelenkofske S, Alexander JH, Harrington RA, Rusconi CP, Becker RC.
Cohen MG, et al. Among authors: myles sk.
Circulation. 2010 Aug 10;122(6):614-22. doi: 10.1161/CIRCULATIONAHA.109.927756. Epub 2010 Jul 26.
Circulation. 2010.
PMID: 20660806
Clinical Trial.
Item in Clipboard
Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trial.
Melloni C, Fier I, Roach J, Kosinski AS, Broderick S, Sigmon K, Myles S, Becker RC, Rao SV; EMINENCE Investigators.
Melloni C, et al.
Am Heart J. 2009 Nov;158(5):726-33. doi: 10.1016/j.ahj.2009.08.020. Epub 2009 Sep 30.
Am Heart J. 2009.
PMID: 19853689
Clinical Trial.
Item in Clipboard
The effect of aspirin on endothelial progenitor cell biology: preliminary investigation of novel properties.
Lou J, Povsic TJ, Allen JD, Adams SD, Myles S, Starr AZ, Ortel TL, Becker RC.
Lou J, et al.
Thromb Res. 2010 Sep;126(3):e175-9. doi: 10.1016/j.thromres.2009.11.017. Epub 2010 Jul 24.
Thromb Res. 2010.
PMID: 20659762
Free PMC article.
Clinical Trial.
Item in Clipboard
Improved surgeon performance in clinical trials: an analysis of quality assurance audits from the American College of Surgeons Oncology Group.
You YN, Jacobs L, Martinez ED, Budinger SC, Wittlief EJ, Myles SK, Ota DM; American College of Surgeons Oncology Group.
You YN, et al. Among authors: myles sk.
J Am Coll Surg. 2006 Sep;203(3):269-76. doi: 10.1016/j.jamcollsurg.2006.05.298. Epub 2006 Jul 13.
J Am Coll Surg. 2006.
PMID: 16931297
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