Chockalingam PS - Search Results

1

Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.

LaVallie ER, Chockalingam PS, Collins-Racie LA, Freeman BA, Keohan CC, Leitges M, Dorner AJ, Morris EA, Majumdar MK, Arai M. LaVallie ER, et al. Among authors: chockalingam ps. J Biol Chem. 2006 Aug 25;281(34):24124-37. doi: 10.1074/jbc.M601905200. Epub 2006 Jun 23. J Biol Chem. 2006. PMID: 16798739 Free article.

2

Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites.

Flannery CR, Zeng W, Corcoran C, Collins-Racie LA, Chockalingam PS, Hebert T, Mackie SA, McDonagh T, Crawford TK, Tomkinson KN, LaVallie ER, Morris EA. Flannery CR, et al. Among authors: chockalingam ps. J Biol Chem. 2002 Nov 8;277(45):42775-80. doi: 10.1074/jbc.M205309200. Epub 2002 Aug 28. J Biol Chem. 2002. PMID: 12202483 Free article.

3

Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1.

Majumdar MK, Chockalingam PS, Bhat RA, Sheldon R, Keohan C, Blanchet T, Glasson S, Morris EA. Majumdar MK, et al. Among authors: chockalingam ps. J Cell Physiol. 2008 Apr;215(1):68-76. doi: 10.1002/jcp.21282. J Cell Physiol. 2008. PMID: 17960567

4

Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes.

Chockalingam PS, Varadarajan U, Sheldon R, Fortier E, LaVallie ER, Morris EA, Yaworsky PJ, Majumdar MK. Chockalingam PS, et al. Arthritis Rheum. 2007 Dec;56(12):4074-83. doi: 10.1002/art.23043. Arthritis Rheum. 2007. PMID: 18050214 Free article.

5

Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).

Chockalingam PS, Zeng W, Morris EA, Flannery CR. Chockalingam PS, et al. Arthritis Rheum. 2004 Sep;50(9):2839-48. doi: 10.1002/art.20496. Arthritis Rheum. 2004. PMID: 15457452 Free article.

6

Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype.

Majumdar MK, Chockalingam PS, Bhat RA, Sheldon R, Keohan C, Blanchet T, Glasson S, Morris EA. Majumdar MK, et al. Among authors: chockalingam ps. J Cell Physiol. 2006 Nov;209(2):551-9. doi: 10.1002/jcp.20775. J Cell Physiol. 2006. PMID: 16883582

7

Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage.

Patel L, Sun W, Glasson SS, Morris EA, Flannery CR, Chockalingam PS. Patel L, et al. Among authors: chockalingam ps. BMC Musculoskelet Disord. 2011 Jul 15;12:164. doi: 10.1186/1471-2474-12-164. BMC Musculoskelet Disord. 2011. PMID: 21762512 Free PMC article.

8

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.

Hu Y, Xing L, Thomason JR, Xiang J, Ipek M, Guler S, Li H, Sabatini J, Chockalingam P, Reifenberg E, Sheldon R, Morris EA, Georgiadis KE, Tam S. Hu Y, et al. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6800-3. doi: 10.1016/j.bmcl.2011.09.036. Epub 2011 Sep 18. Bioorg Med Chem Lett. 2011. PMID: 21982494

9

Synthesis and SAR of highly selective MMP-13 inhibitors.

Li J, Rush TS 3rd, Li W, DeVincentis D, Du X, Hu Y, Thomason JR, Xiang JS, Skotnicki JS, Tam S, Cunningham KM, Chockalingam PS, Morris EA, Levin JI. Li J, et al. Among authors: chockalingam ps. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6. doi: 10.1016/j.bmcl.2005.08.001. Bioorg Med Chem Lett. 2005. PMID: 16153831

10

3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.

Li W, Hu Y, Li J, Thomason JR, DeVincentis D, Du X, Wu J, Hotchandani R, Rush TS 3rd, Skotnicki JS, Tam S, Chockalingam PS, Morris EA, Levin JI. Li W, et al. Among authors: chockalingam ps. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4546-50. doi: 10.1016/j.bmcl.2009.07.008. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19625186

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