Grace JE Jr - Search Results

1

Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF₁) receptor antagonists.

Ahuja VT, Hartz RA, Molski TF, Mattson GK, Lentz KA, Grace JE Jr, Lodge NJ, Bronson JJ, Macor JE. Ahuja VT, et al. Among authors: grace je jr. Bioorg Med Chem Lett. 2016 May 1;26(9):2184-7. doi: 10.1016/j.bmcl.2016.03.067. Epub 2016 Mar 17. Bioorg Med Chem Lett. 2016. PMID: 27020524

2

[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.

Deskus JA, Dischino DD, Mattson RJ, Ditta JL, Parker MF, Denhart DJ, Zuev D, Huang H, Hartz RA, Ahuja VT, Wong H, Mattson GK, Molski TF, Grace JE Jr, Zueva L, Nielsen JM, Dulac H, Li YW, Guaraldi M, Azure M, Onthank D, Hayes M, Wexler E, McDonald J, Lodge NJ, Bronson JJ, Macor JE. Deskus JA, et al. Among authors: grace je jr. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6651-5. doi: 10.1016/j.bmcl.2012.08.112. Epub 2012 Sep 7. Bioorg Med Chem Lett. 2012. PMID: 23010264

3

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

Wei C, Grace JE Jr, Zvyaga TA, Drexler DM. Wei C, et al. Among authors: grace je jr. Bioanalysis. 2012 Aug;4(15):1895-905. doi: 10.4155/bio.12.151. Bioanalysis. 2012. PMID: 22943620

4

Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor.

He K, Luettgen JM, Zhang D, He B, Grace JE Jr, Xin B, Pinto DJ, Wong PC, Knabb RM, Lam PY, Wexler RR, Grossman SJ. He K, et al. Among authors: grace je jr. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):129-39. doi: 10.1007/s13318-011-0037-x. Epub 2011 Apr 2. Eur J Drug Metab Pharmacokinet. 2011. PMID: 21461793

5

Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.

Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE Jr, Simmermacher J, Dulac HA, Pizzano J, Sinz M. Kim S, et al. Among authors: grace je jr. Drug Metab Dispos. 2010 Jan;38(1):16-24. doi: 10.1124/dmd.109.029637. Drug Metab Dispos. 2010. PMID: 19833845

6

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF. Meredith JE Jr, et al. Among authors: grace je jr. J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. doi: 10.1124/jpet.108.138974. Epub 2008 May 22. J Pharmacol Exp Ther. 2008. PMID: 18499745

7

6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.

Wong H, Dockens RC, Pajor L, Yeola S, Grace JE Jr, Stark AD, Taub RA, Yocca FD, Zaczek RC, Li YW. Wong H, et al. Among authors: grace je jr. Drug Metab Dispos. 2007 Aug;35(8):1387-92. doi: 10.1124/dmd.107.015768. Epub 2007 May 9. Drug Metab Dispos. 2007. PMID: 17494642

8

Glucuronidation in the chimpanzee (Pan troglodytes): studies with acetaminophen, oestradiol and morphine.

Wong H, Grace JE Jr, Wright MR, Browning MR, Grossman SJ, Bai SA, Christ DD. Wong H, et al. Among authors: grace je jr. Xenobiotica. 2006 Dec;36(12):1178-90. doi: 10.1080/00498250600911028. Xenobiotica. 2006. PMID: 17162465

9

Development and validation of a preclinical food effect model.

Lentz KA, Quitko M, Morgan DG, Grace JE Jr, Gleason C, Marathe PH. Lentz KA, et al. Among authors: grace je jr. J Pharm Sci. 2007 Feb;96(2):459-72. doi: 10.1002/jps.20767. J Pharm Sci. 2007. PMID: 17075867

10

Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists.

Gillman KW, Higgins MA, Poindexter GS, Browning M, Clarke WJ, Flowers S, Grace JE Jr, Hogan JB, McGovern RT, Iben LG, Mattson GK, Ortiz A, Rassnick S, Russell JW, Antal-Zimanyi I. Gillman KW, et al. Among authors: grace je jr. Bioorg Med Chem. 2006 Aug 15;14(16):5517-26. doi: 10.1016/j.bmc.2006.04.042. Epub 2006 May 11. Bioorg Med Chem. 2006. PMID: 16697206

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