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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Vannini A, Volpari C, Filocamo G, Casavola EC, Brunetti M, Renzoni D, Chakravarty P, Paolini C, De Francesco R, Gallinari P, Steinkühler C, Di Marco S. Vannini A, et al. Among authors: filocamo g. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15064-9. doi: 10.1073/pnas.0404603101. Epub 2004 Oct 11. Proc Natl Acad Sci U S A. 2004. PMID: 15477595 Free PMC article.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.
Malancona S, Altamura S, Filocamo G, Kinzel O, Hernando JI, Rowley M, Scarpelli R, Steinkühler C, Jones P. Malancona S, et al. Among authors: filocamo g. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4422-8. doi: 10.1016/j.bmcl.2011.06.024. Epub 2011 Jun 16. Bioorg Med Chem Lett. 2011. PMID: 21737272
Smoothened antagonists: a promising new class of antitumor agents.
Gallinari P, Filocamo G, Jones P, Pazzaglia S, Steinkühler C. Gallinari P, et al. Among authors: filocamo g. Expert Opin Drug Discov. 2009 May;4(5):525-44. doi: 10.1517/17460440902852686. Expert Opin Drug Discov. 2009. PMID: 23485085
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.
Kinzel O, Alfieri A, Altamura S, Brunetti M, Bufali S, Colaceci F, Ferrigno F, Filocamo G, Fonsi M, Gallinari P, Malancona S, Hernando JI, Monteagudo E, Orsale MV, Palumbi MC, Pucci V, Rowley M, Sasso R, Scarpelli R, Steinkühler C, Jones P. Kinzel O, et al. Among authors: filocamo g. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4429-35. doi: 10.1016/j.bmcl.2011.06.023. Epub 2011 Jun 16. Bioorg Med Chem Lett. 2011. PMID: 21737263
180 results