Osawa S - Search Results

1

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Kakuda N, et al. Among authors: osawa s. J Biol Chem. 2006 May 26;281(21):14776-86. doi: 10.1074/jbc.M513453200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595682 Free article.

2

Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states.

Osawa S, Funamoto S, Nobuhara M, Wada-Kakuda S, Shimojo M, Yagishita S, Ihara Y. Osawa S, et al. J Biol Chem. 2008 Jul 11;283(28):19283-92. doi: 10.1074/jbc.M705954200. Epub 2008 May 14. J Biol Chem. 2008. PMID: 18480063 Free article.

3

Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.

Kang MS, Baek SH, Chun YS, Moore AZ, Landman N, Berman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S, Kim TW. Kang MS, et al. Among authors: osawa s. J Biol Chem. 2013 Jul 19;288(29):20868-20882. doi: 10.1074/jbc.M112.445734. Epub 2013 May 30. J Biol Chem. 2013. PMID: 23723072 Free PMC article.

4

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T. Hayashi I, et al. Among authors: osawa s. J Biol Chem. 2009 Oct 9;284(41):27838-27847. doi: 10.1074/jbc.M109.055061. Epub 2009 Aug 14. J Biol Chem. 2009. PMID: 19684016 Free PMC article.

5

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.

Futai E, Osawa S, Cai T, Fujisawa T, Ishiura S, Tomita T. Futai E, et al. Among authors: osawa s. J Biol Chem. 2016 Jan 1;291(1):435-46. doi: 10.1074/jbc.M114.629287. Epub 2015 Nov 11. J Biol Chem. 2016. PMID: 26559975 Free PMC article.

6

Three-dimensional structure of the signal peptide peptidase.

Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T. Miyashita H, et al. Among authors: osawa s. J Biol Chem. 2011 Jul 22;286(29):26188-97. doi: 10.1074/jbc.M111.260273. Epub 2011 Jun 2. J Biol Chem. 2011. PMID: 21636854 Free PMC article.

7

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Ohki Y, et al. Among authors: osawa s. EMBO J. 2011 Oct 14;30(23):4815-24. doi: 10.1038/emboj.2011.372. EMBO J. 2011. PMID: 22002539 Free PMC article.

8

Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.

Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T. Takagi-Niidome S, et al. Among authors: osawa s. Biochemistry. 2013 Jan 8;52(1):61-9. doi: 10.1021/bi301252r. Epub 2012 Dec 14. Biochemistry. 2013. PMID: 23210549

9

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation.

Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Ohki Y, et al. Among authors: osawa s. Mol Neurodegener. 2014 Jan 13;9:7. doi: 10.1186/1750-1326-9-7. Mol Neurodegener. 2014. PMID: 24410857 Free PMC article.

10

Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.

Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T. Takagi-Niidome S, et al. Among authors: osawa s. J Neurosci. 2015 Feb 11;35(6):2646-56. doi: 10.1523/JNEUROSCI.3164-14.2015. J Neurosci. 2015. PMID: 25673856 Free PMC article.

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