The design and synthesis of a potent Angiotensin II cyclic analogue confirms the ring cluster receptor conformation of the hormone Angiotensin II.
Matsoukas JM, Polevaya L, Ancans J, Mavromoustakos T, Kolocouris A, Roumelioti P, Vlahakos DV, Yamdagni R, Wu Q, Moore GJ.
Matsoukas JM, et al. Among authors: mavromoustakos t.
Bioorg Med Chem. 2000 Jan;8(1):1-10. doi: 10.1016/s0968-0896(99)00266-7.
Bioorg Med Chem. 2000.
PMID: 10968258
The obtained results using a combination of 2D NMR, 1D NOE spectroscopy and molecular modeling revealed a similar Tyr4-Ile5-His6 bend, a His6-Pro7 trans configuration and a side chain aromatic ring cluster of the key aminoacids Tyr4, His6, Phe8 for c-[Sar1,Lys3,Glu5] ANG II as it …
The obtained results using a combination of 2D NMR, 1D NOE spectroscopy and molecular modeling revealed a similar Tyr4-Ile5-His6 bend, a His …