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(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
J Med Chem. 2005 Dec 29;48(26):8163-73. doi: 10.1021/jm050680m.
J Med Chem. 2005.
PMID: 16366598
Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2).
Garrabrant T, Tuman RW, Ludovici D, Tominovich R, Simoneaux RL, Galemmo RA Jr, Johnson DL.
Garrabrant T, et al.
Angiogenesis. 2004;7(2):91-6. doi: 10.1007/s10456-004-6089-7.
Angiogenesis. 2004.
PMID: 15516829
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A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models.
Emanuel S, Gruninger RH, Fuentes-Pesquera A, Connolly PJ, Seamon JA, Hazel S, Tominovich R, Hollister B, Napier C, D'Andrea MR, Reuman M, Bignan G, Tuman R, Johnson D, Moffatt D, Batchelor M, Foley A, O'Connell J, Allen R, Perry M, Jolliffe L, Middleton SA.
Emanuel S, et al.
Mol Pharmacol. 2004 Sep;66(3):635-47. doi: 10.1124/mol.104.000638.
Mol Pharmacol. 2004.
PMID: 15322256
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Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives.
Bongartz JP, Stokbroekx R, Van der Aa M, Luyckx M, Willems M, Ceusters M, Meerpoel L, Smets G, Jansen T, Wouters W, Bowden C, Valletta L, Herb M, Tominovich R, Tuman R.
Bongartz JP, et al.
Bioorg Med Chem Lett. 2002 Feb 25;12(4):589-91. doi: 10.1016/s0960-894x(01)00805-8.
Bioorg Med Chem Lett. 2002.
PMID: 11844678
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Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo.
Koblish HK, Zhao S, Franks CF, Donatelli RR, Tominovich RM, LaFrance LV, Leonard KA, Gushue JM, Parks DJ, Calvo RR, Milkiewicz KL, Marugán JJ, Raboisson P, Cummings MD, Grasberger BL, Johnson DL, Lu T, Molloy CJ, Maroney AC.
Koblish HK, et al. Among authors: tominovich rm.
Mol Cancer Ther. 2006 Jan;5(1):160-9. doi: 10.1158/1535-7163.MCT-05-0199.
Mol Cancer Ther. 2006.
PMID: 16432175
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