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Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD.
Sparks DL, Sabbagh MN, Connor DJ, Lopez J, Launer LJ, Petanceska S, Browne P, Wassar D, Johnson-Traver S, Lochhead J, Ziolkowski C. Sparks DL, et al. Among authors: browne p. Curr Alzheimer Res. 2005 Jul;2(3):343-53. doi: 10.2174/1567205054367900. Curr Alzheimer Res. 2005. PMID: 15974900 Clinical Trial.
Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial.
Sparks DL, Connor DJ, Sabbagh MN, Petersen RB, Lopez J, Browne P. Sparks DL, et al. Among authors: browne p. Acta Neurol Scand Suppl. 2006;185:3-7. doi: 10.1111/j.1600-0404.2006.00690.x. Acta Neurol Scand Suppl. 2006. PMID: 16866904 Clinical Trial.
Statin therapy in Alzheimer's disease.
Sparks DL, Sabbagh M, Connor D, Soares H, Lopez J, Stankovic G, Johnson-Traver S, Ziolkowski C, Browne P. Sparks DL, et al. Among authors: browne p. Acta Neurol Scand Suppl. 2006;185:78-86. doi: 10.1111/j.1600-0404.2006.00689.x. Acta Neurol Scand Suppl. 2006. PMID: 16866915 Review.
A position paper: based on observational data indicating an increased rate of altered blood chemistry requiring withdrawal from the Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT).
Sparks DL, Lopez J, Connor D, Sabbagh M, Seward J, Browne P; Alzheimer's Disease Cholesterol-Lowering Treatment Team. Sparks DL, et al. Among authors: browne p. J Mol Neurosci. 2003;20(3):407-10. doi: 10.1385/JMN:20:3:407. J Mol Neurosci. 2003. PMID: 14501025 Clinical Trial.
Adverse effects in traditional and alternative toxicity tests.
Browne P, Paul Friedman K, Boekelheide K, Thomas RS. Browne P, et al. Regul Toxicol Pharmacol. 2024 Mar;148:105579. doi: 10.1016/j.yrtph.2024.105579. Epub 2024 Feb 1. Regul Toxicol Pharmacol. 2024. PMID: 38309424 Free article.
346 results