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In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
J Med Chem. 2005 Mar 24;48(6):1901-9. doi: 10.1021/jm040840e.
J Med Chem. 2005.
PMID: 15771434
Review.
Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues.
Breslin HJ, Kukla MJ, Kromis T, Cullis H, De Knaep F, Pauwels R, Andries K, De Clercq E, Janssen MA, Janssen PA.
Breslin HJ, et al. Among authors: de knaep f.
Bioorg Med Chem. 1999 Nov;7(11):2427-36. doi: 10.1016/s0968-0896(99)00198-4.
Bioorg Med Chem. 1999.
PMID: 10632052
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