Hirokawa T - Search Results

1

Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system.

Demura M, Yoshida T, Hirokawa T, Kumaki Y, Aizawa T, Nitta K, Bitter I, Tóth K. Demura M, et al. Among authors: hirokawa t. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1367-70. doi: 10.1016/j.bmcl.2005.01.012. Bioorg Med Chem Lett. 2005. PMID: 15713388

2

Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger.

Tsuzuki T, Sakaguchi N, Kudoh T, Takano S, Uehara M, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Potter BV, Fukuda H, Arisawa M, Shuto S. Tsuzuki T, et al. Among authors: hirokawa t. Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6633-7. doi: 10.1002/anie.201302098. Epub 2013 May 13. Angew Chem Int Ed Engl. 2013. PMID: 23670921 Free PMC article. No abstract available.

3

Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy.

Watanabe M, Hirokawa T, Kobayashi T, Yoshida A, Ito Y, Yamada S, Orimoto N, Yamasaki Y, Arisawa M, Shuto S. Watanabe M, et al. Among authors: hirokawa t. J Med Chem. 2010 May 13;53(9):3585-93. doi: 10.1021/jm901848b. J Med Chem. 2010. PMID: 20397706

4

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose.

Tsuzuki T, Takano S, Sakaguchi N, Kudoh T, Murayama T, Sakurai T, Hashii M, Higashida H, Weber K, Guse AH, Kameda T, Hirokawa T, Kumaki Y, Arisawa M, Potter BV, Shuto S. Tsuzuki T, et al. Among authors: hirokawa t. Messenger (Los Angel). 2014 Jun-Dec;3(1-2):35-51. doi: 10.1166/msr.2014.1035. Epub 2014 Jun 1. Messenger (Los Angel). 2014. PMID: 27200225 Free PMC article.

5

Investigation of the noncovalent binding mode of covalent proteasome inhibitors around the transition state by combined use of cyclopropylic strain-based conformational restriction and computational modeling.

Kawamura S, Unno Y, Tanaka M, Sasaki T, Yamano A, Hirokawa T, Kameda T, Asai A, Arisawa M, Shuto S. Kawamura S, et al. Among authors: hirokawa t. J Med Chem. 2013 Jul 25;56(14):5829-42. doi: 10.1021/jm400542h. Epub 2013 Jul 9. J Med Chem. 2013. PMID: 23837692

6

Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS₁ by Docking-Aided Structure-Activity Analysis.

Sayama M, Inoue A, Nakamura S, Jung S, Ikubo M, Otani Y, Uwamizu A, Kishi T, Makide K, Aoki J, Hirokawa T, Ohwada T. Sayama M, et al. Among authors: hirokawa t. J Med Chem. 2017 Jul 27;60(14):6384-6399. doi: 10.1021/acs.jmedchem.7b00693. Epub 2017 Jul 17. J Med Chem. 2017. PMID: 28715213

7

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer.

Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, Hirokawa T, Natsume T, Doi T. Ohsawa K, et al. Among authors: hirokawa t. Bioorg Med Chem. 2018 Dec 15;26(23-24):6023-6034. doi: 10.1016/j.bmc.2018.11.001. Epub 2018 Nov 7. Bioorg Med Chem. 2018. PMID: 30455074

8

Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening.

Usui T, Ban HS, Kawada J, Hirokawa T, Nakamura H. Usui T, et al. Among authors: hirokawa t. Bioorg Med Chem Lett. 2008 Jan 1;18(1):285-8. doi: 10.1016/j.bmcl.2007.10.084. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 17983745

9

Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor.

Nakagita T, Ishida A, Matsuya T, Kobayashi T, Narukawa M, Hirokawa T, Hashimoto M, Misaka T. Nakagita T, et al. Among authors: hirokawa t. PLoS One. 2019 Mar 18;14(3):e0213552. doi: 10.1371/journal.pone.0213552. eCollection 2019. PLoS One. 2019. PMID: 30883570 Free PMC article.

10

Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: histamine H3 and/or H4 receptor ligands with the 2,3-methanobutane backbone.

Watanabe M, Kobayashi T, Hirokawa T, Yoshida A, Ito Y, Yamada S, Orimoto N, Yamasaki Y, Arisawa M, Shuto S. Watanabe M, et al. Among authors: hirokawa t. Org Biomol Chem. 2012 Jan 28;10(4):736-45. doi: 10.1039/c1ob06496g. Epub 2011 Nov 28. Org Biomol Chem. 2012. PMID: 22120611

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