Trevillyan JM - Search Results

1

Expression, purification, and enzymatic characterization of the dual specificity mitogen-activated protein kinase phosphatase, MKP-4.

Hong SB, Lubben TH, Dolliver CM, Petrolonis AJ, Roy RA, Li Z, Parsons TF, Li P, Xu H, Reilly RM, Trevillyan JM, Nichols AJ, Tummino PJ, Gant TG. Hong SB, et al. Among authors: trevillyan jm. Bioorg Chem. 2005 Feb;33(1):34-44. doi: 10.1016/j.bioorg.2004.08.001. Bioorg Chem. 2005. PMID: 15668181

2

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.

Xin Z, Liu G, Abad-Zapatero C, Pei Z, Szczepankiewicz BG, Li X, Zhang T, Hutchins CW, Hajduk PJ, Ballaron SJ, Stashko MA, Lubben TH, Trevillyan JM, Jirousek MR. Xin Z, et al. Among authors: trevillyan jm. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3947-50. doi: 10.1016/j.bmcl.2003.08.064. Bioorg Med Chem Lett. 2003. PMID: 14592481

3

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

Zhao H, Liu G, Xin Z, Serby MD, Pei Z, Szczepankiewicz BG, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR. Zhao H, et al. Among authors: trevillyan jm. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5543-6. doi: 10.1016/j.bmcl.2004.08.063. Bioorg Med Chem Lett. 2004. PMID: 15482920

4

Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.

Liu G, Xin Z, Liang H, Abad-Zapatero C, Hajduk PJ, Janowick DA, Szczepankiewicz BG, Pei Z, Hutchins CW, Ballaron SJ, Stashko MA, Lubben TH, Berg CE, Rondinone CM, Trevillyan JM, Jirousek MR. Liu G, et al. Among authors: trevillyan jm. J Med Chem. 2003 Jul 31;46(16):3437-40. doi: 10.1021/jm034088d. J Med Chem. 2003. PMID: 12877578

5

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM. Szczepankiewicz BG, et al. Among authors: trevillyan jm. J Med Chem. 2006 Jun 15;49(12):3563-80. doi: 10.1021/jm060199b. J Med Chem. 2006. PMID: 16759099

6

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.

Clampit JE, Meuth JL, Smith HT, Reilly RM, Jirousek MR, Trevillyan JM, Rondinone CM. Clampit JE, et al. Among authors: trevillyan jm. Biochem Biophys Res Commun. 2003 Jan 10;300(2):261-7. doi: 10.1016/s0006-291x(02)02839-5. Biochem Biophys Res Commun. 2003. PMID: 12504077

7

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.

Liu G, Xin Z, Pei Z, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Zhao H, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR. Liu G, et al. Among authors: trevillyan jm. J Med Chem. 2003 Sep 25;46(20):4232-5. doi: 10.1021/jm034122o. J Med Chem. 2003. PMID: 13678400

8

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.

Szczepankiewicz BG, Liu G, Hajduk PJ, Abad-Zapatero C, Pei Z, Xin Z, Lubben TH, Trevillyan JM, Stashko MA, Ballaron SJ, Liang H, Huang F, Hutchins CW, Fesik SW, Jirousek MR. Szczepankiewicz BG, et al. Among authors: trevillyan jm. J Am Chem Soc. 2003 Apr 9;125(14):4087-96. doi: 10.1021/ja0296733. J Am Chem Soc. 2003. PMID: 12670229

9

Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.

Backes BJ, Longenecker K, Hamilton GL, Stewart K, Lai C, Kopecka H, von Geldern TW, Madar DJ, Pei Z, Lubben TH, Zinker BA, Tian Z, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Kempf-Grote AJ, Black-Schaefer C, Sham HL, Trevillyan JM. Backes BJ, et al. Among authors: trevillyan jm. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2005-12. doi: 10.1016/j.bmcl.2007.01.026. Epub 2007 Jan 19. Bioorg Med Chem Lett. 2007. PMID: 17276063

10

In vitro enzymatic assays of protein tyrosine phosphatase 1B.

Lubben T, Clampit J, Stashko M, Trevillyan J, Jirousek MR. Lubben T, et al. Curr Protoc Pharmacol. 2001 Aug;Chapter 3:Unit3.8. doi: 10.1002/0471141755.ph0308s13. Curr Protoc Pharmacol. 2001. PMID: 21959757

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