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Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.
Medchemcomm. 2016 Nov 22;8(4):771-779. doi: 10.1039/c6md00564k. eCollection 2017 Apr 1.
Medchemcomm. 2016.
PMID: 30108796
Free PMC article.
Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys.
Watson KJ, Gorczyca WP, Umland J, Zhang Y, Chen X, Sun SZ, Fermini B, Holbrook M, Van Der Graaf PH.
Watson KJ, et al. Among authors: gorczyca wp.
J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):304-13. doi: 10.1016/j.vascn.2011.03.002. Epub 2011 Mar 17.
J Pharmacol Toxicol Methods. 2011.
PMID: 21419854
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Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.
Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X, Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M, Mansour TS, O'Connell JF.
Howe AY, et al. Among authors: gorczyca wp.
Antimicrob Agents Chemother. 2004 Dec;48(12):4813-21. doi: 10.1128/AAC.48.12.4813-4821.2004.
Antimicrob Agents Chemother. 2004.
PMID: 15561861
Free PMC article.
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Comparisons of the depressor, inotropic and renal effects of milrinone and CI-930 to different pure vasodilators and diuretics in conscious instrumented dogs.
Lee KC, Clas DM, Gorczyca WP, Silver PJ, Ezrin AM.
Lee KC, et al. Among authors: gorczyca wp.
Drugs Exp Clin Res. 1991;17(7):323-36.
Drugs Exp Clin Res. 1991.
PMID: 1686584
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