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Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans.
O'Mahony L, O'Callaghan L, McCarthy J, Shilling D, Scully P, Sibartie S, Kavanagh E, Kirwan WO, Redmond HP, Collins JK, Shanahan F. O'Mahony L, et al. Among authors: mccarthy j. Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G839-45. doi: 10.1152/ajpgi.00112.2005. Epub 2005 Nov 17. Am J Physiol Gastrointest Liver Physiol. 2006. PMID: 16293657 Free article.
Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.
Woznicki JA, Flood P, Bustamante-Garrido M, Stamou P, Moloney G, Fanning A, Zulquernain SA, McCarthy J, Shanahan F, Melgar S, Nally K. Woznicki JA, et al. Among authors: mccarthy j. Cell Death Dis. 2020 Jan 27;11(1):68. doi: 10.1038/s41419-020-2263-0. Cell Death Dis. 2020. PMID: 31988296 Free PMC article.
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Woznicki JA, Saini N, Flood P, Rajaram S, Lee CM, Stamou P, Skowyra A, Bustamante-Garrido M, Regazzoni K, Crawford N, McDade SS, Longley DB, Aza-Blanc P, Shanahan F, Zulquernain SA, McCarthy J, Melgar S, McRae BL, Nally K. Woznicki JA, et al. Among authors: mccarthy j. Cell Death Dis. 2021 Sep 23;12(10):864. doi: 10.1038/s41419-021-04151-3. Cell Death Dis. 2021. PMID: 34556638 Free PMC article.
DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids.
Flood P, Fanning A, Woznicki JA, Crowley T, Christopher A, Vaccaro A, Houston A, McSweeney S, Ross S, Hogan A, Brint E, Skowyra A, Bustamante M, Ambrose M, Moloney G, MacSharry J, Hammarström ML, Hurley M, Fitzgibbons C, Quigley EMM, Shanahan F, Zulquernain SA, McCarthy J, Dodson GS, Dabbagh K, McRae BL, Melgar S, Nally K. Flood P, et al. Among authors: mccarthy j. Am J Physiol Gastrointest Liver Physiol. 2022 Nov 1;323(5):G439-G460. doi: 10.1152/ajpgi.00104.2022. Epub 2022 Sep 27. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 36165492 Free article.
Irish data on the safety and efficacy of vedolizumab in the treatment of inflammatory bowel disease.
Judge C, McGettigan N, Ryan T, Hazel K, Singh P, Parihar V, Stack R, O'Connor A, Dunne C, Cullen G, Egan L, Harewood G, MacCarthy F, McKiernan S, Mulcahy H, Murray F, Patchett S, Sheridan J, Cheriyan D, Farrell R, Keohane J, Kelly O, McNamara D, Ryan B, O'Morain C, Sengupta S, O'Toole A, Buckley M, McCarthy J, Doherty G, Kevans D, Slattery E. Judge C, et al. Among authors: mccarthy j. Scand J Gastroenterol. 2020 Jul;55(7):786-794. doi: 10.1080/00365521.2020.1779340. Epub 2020 Jun 16. Scand J Gastroenterol. 2020. PMID: 32544012
Protocol for a multicentred randomised controlled trial investigating the use of personalised golimumab dosing tailored to inflammatory load in ulcerative colitis: the GOAL-ARC study (GLM dose Optimisation to Adequate Levels to Achieve Response in Colitis) led by the INITIAtive group (NCT 0268772).
Sheridan J, Coe CA, Doran P, Egan L, Cullen G, Kevans D, Leyden J, Galligan M, O'Toole A, McCarthy J, Doherty G. Sheridan J, et al. Among authors: mccarthy j. BMJ Open Gastroenterol. 2018 Jan 11;5(1):e000174. doi: 10.1136/bmjgast-2017-000174. eCollection 2018. BMJ Open Gastroenterol. 2018. PMID: 29379609 Free PMC article.
3,406 results