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A practical synthesis of gramicidin s and sugar amino Acid containing analogues.
Grotenbreg GM, Kronemeijer M, Timmer MS, El Oualid F, van Well RM, Verdoes M, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Boom JH, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. Among authors: de neeling aj. J Org Chem. 2004 Nov 12;69(23):7851-9. doi: 10.1021/jo0487449. J Org Chem. 2004. PMID: 15527261
Synthesis and biological evaluation of gramicidin S dimers.
Grotenbreg GM, Witte MD, van Hoof PA, Spalburg E, Reiss P, Noort D, de Neeling AJ, Koert U, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. Among authors: de neeling aj. Org Biomol Chem. 2005 Jan 21;3(2):233-8. doi: 10.1039/b414618b. Org Biomol Chem. 2005. PMID: 15717418
Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product.
Grotenbreg GM, Buizert AE, Llamas-Saiz AL, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. Among authors: de neeling aj. J Am Chem Soc. 2006 Jun 14;128(23):7559-65. doi: 10.1021/ja0588510. J Am Chem Soc. 2006. PMID: 16756311
Structural and biological evaluation of some loloatin C analogues.
Tuin AW, Grotenbreg GM, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, van der Marel GA, Noort D, Overkleeft HS, Overhand M. Tuin AW, et al. Among authors: de neeling aj. Bioorg Med Chem. 2009 Sep 1;17(17):6233-40. doi: 10.1016/j.bmc.2009.07.049. Epub 2009 Jul 25. Bioorg Med Chem. 2009. PMID: 19679485
An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity.
Kapoerchan VV, Knijnenburg AD, Niamat M, Spalburg E, de Neeling AJ, Nibbering PH, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Kapoerchan VV, et al. Among authors: de neeling aj. Chemistry. 2010 Oct 25;16(40):12174-81. doi: 10.1002/chem.201001686. Chemistry. 2010. PMID: 20848624
Exploring the conformational and biological versatility of β-turn-modified gramicidin S by using sugar amino acid homologues that vary in ring size.
Knijnenburg AD, Tuin AW, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Knijnenburg AD, et al. Among authors: de neeling aj. Chemistry. 2011 Mar 28;17(14):3995-4004. doi: 10.1002/chem.201002895. Epub 2011 Mar 1. Chemistry. 2011. PMID: 21365698
81 results