Grotenbreg GM - Search Results

1

A practical synthesis of gramicidin s and sugar amino Acid containing analogues.

Grotenbreg GM, Kronemeijer M, Timmer MS, El Oualid F, van Well RM, Verdoes M, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Boom JH, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. J Org Chem. 2004 Nov 12;69(23):7851-9. doi: 10.1021/jo0487449. J Org Chem. 2004. PMID: 15527261

2

Synthesis and biological evaluation of novel turn-modified gramicidin S analogues.

Grotenbreg GM, Spalburg E, de Neeling AJ, van der Marel GA, Overkleeft HS, van Boom JH, Overhand M. Grotenbreg GM, et al. Bioorg Med Chem. 2003 Jul 3;11(13):2835-41. doi: 10.1016/s0968-0896(03)00219-0. Bioorg Med Chem. 2003. PMID: 12788356

3

An unusual reverse turn structure adopted by a furanoid sugar amino acid incorporated in gramicidin S.

Grotenbreg GM, Timmer MS, Llamas-Saiz AL, Verdoes M, van der Marel GA, van Raaij MJ, Overkleeft HS, Overhand M. Grotenbreg GM, et al. J Am Chem Soc. 2004 Mar 24;126(11):3444-6. doi: 10.1021/ja0397254. J Am Chem Soc. 2004. PMID: 15025470

4

Synthesis and application of carbohydrate-derived morpholine amino acids.

Grotenbreg GM, Christina AE, Buizert AE, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. J Org Chem. 2004 Nov 26;69(24):8331-9. doi: 10.1021/jo048630x. J Org Chem. 2004. PMID: 15549804

5

Synthesis and biological evaluation of gramicidin S dimers.

Grotenbreg GM, Witte MD, van Hoof PA, Spalburg E, Reiss P, Noort D, de Neeling AJ, Koert U, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. Org Biomol Chem. 2005 Jan 21;3(2):233-8. doi: 10.1039/b414618b. Org Biomol Chem. 2005. PMID: 15717418

6

Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product.

Grotenbreg GM, Buizert AE, Llamas-Saiz AL, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Grotenbreg GM, et al. J Am Chem Soc. 2006 Jun 14;128(23):7559-65. doi: 10.1021/ja0588510. J Am Chem Soc. 2006. PMID: 16756311

7

Structural and biological evaluation of some loloatin C analogues.

Tuin AW, Grotenbreg GM, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, van der Marel GA, Noort D, Overkleeft HS, Overhand M. Tuin AW, et al. Among authors: grotenbreg gm. Bioorg Med Chem. 2009 Sep 1;17(17):6233-40. doi: 10.1016/j.bmc.2009.07.049. Epub 2009 Jul 25. Bioorg Med Chem. 2009. PMID: 19679485

8

Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity.

Knijnenburg AD, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Grotenbreg GM, van der Marel GA, Overkleeft HS, Overhand M. Knijnenburg AD, et al. Among authors: grotenbreg gm. ChemMedChem. 2009 Dec;4(12):1976-9. doi: 10.1002/cmdc.200900379. ChemMedChem. 2009. PMID: 19862783 No abstract available.

9

Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives.

Knijnenburg AD, Kapoerchan VV, Grotenbreg GM, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, Ravensbergen B, Nibbering PH, van der Marel GA, Overkleeft HS, Overhand M. Knijnenburg AD, et al. Among authors: grotenbreg gm. Bioorg Med Chem. 2011 Jun 1;19(11):3402-9. doi: 10.1016/j.bmc.2011.04.031. Epub 2011 Apr 22. Bioorg Med Chem. 2011. PMID: 21561781

10

Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands.

Bonger KM, Kapoerchan VV, Grotenbreg GM, van Koppen CJ, Timmers CM, van der Marel GA, Overkleeft HS. Bonger KM, et al. Among authors: grotenbreg gm. Org Biomol Chem. 2010 Apr 21;8(8):1881-4. doi: 10.1039/b923556f. Org Biomol Chem. 2010. PMID: 20449493

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