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Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.
Sams AG, Hentzer M, Mikkelsen GK, Larsen K, Bundgaard C, Plath N, Christoffersen CT, Bang-Andersen B. Sams AG, et al. Among authors: christoffersen ct. J Med Chem. 2010 Sep 9;53(17):6386-97. doi: 10.1021/jm100697g. J Med Chem. 2010. PMID: 20684563
Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.
Sams AG, Larsen K, Mikkelsen GK, Hentzer M, Christoffersen CT, Jensen KG, Frederiksen K, Bang-Andersen B. Sams AG, et al. Among authors: christoffersen ct. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5134-40. doi: 10.1016/j.bmcl.2012.05.048. Epub 2012 May 18. Bioorg Med Chem Lett. 2012. PMID: 22677319
Synthesis and SAR study of a novel series of dopamine receptor agonists.
Risgaard R, Jensen M, Jørgensen M, Bang-Andersen B, Christoffersen CT, Jensen KG, Kristensen JL, Püschl A. Risgaard R, et al. Among authors: christoffersen ct. Bioorg Med Chem. 2014 Jan 1;22(1):381-92. doi: 10.1016/j.bmc.2013.11.012. Epub 2013 Nov 15. Bioorg Med Chem. 2014. PMID: 24296012
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors.
Kehler J, Ritzen A, Langgård M, Petersen SL, Farah MM, Bundgaard C, Christoffersen CT, Nielsen J, Kilburn JP. Kehler J, et al. Among authors: christoffersen ct. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3738-42. doi: 10.1016/j.bmcl.2011.04.067. Epub 2011 Apr 30. Bioorg Med Chem Lett. 2011. PMID: 21602043
A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission.
Nielsen J, Fejgin K, Sotty F, Nielsen V, Mørk A, Christoffersen CT, Yavich L, Lauridsen JB, Clausen D, Larsen PH, Egebjerg J, Werge TM, Kallunki P, Christensen KV, Didriksen M. Nielsen J, et al. Among authors: christoffersen ct. Transl Psychiatry. 2017 Nov 30;7(11):1261. doi: 10.1038/s41398-017-0011-8. Transl Psychiatry. 2017. PMID: 29187755 Free PMC article.
41 results