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A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis.
Guo Q, Sahoo SP, Wang PR, Milot DP, Ippolito MC, Wu MS, Baffic J, Biswas C, Hernandez M, Lam MH, Sharma N, Han W, Kelly LJ, MacNaul KL, Zhou G, Desai R, Heck JV, Doebber TW, Berger JP, Moller DE, Sparrow CP, Chao YS, Wright SD. Guo Q, et al. Among authors: wright sd. Endocrinology. 2004 Apr;145(4):1640-8. doi: 10.1210/en.2003-1270. Epub 2003 Dec 30. Endocrinology. 2004. PMID: 14701675
(2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents.
Koyama H, Miller DJ, Boueres JK, Desai RC, Jones AB, Berger JP, MacNaul KL, Kelly LJ, Doebber TW, Wu MS, Zhou G, Wang PR, Ippolito MC, Chao YS, Agrawal AK, Franklin R, Heck JV, Wright SD, Moller DE, Sahoo SP. Koyama H, et al. Among authors: wright sd. J Med Chem. 2004 Jun 3;47(12):3255-63. doi: 10.1021/jm030621d. J Med Chem. 2004. PMID: 15163205
PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.
Hermanowski-Vosatka A, Gerhold D, Mundt SS, Loving VA, Lu M, Chen Y, Elbrecht A, Wu M, Doebber T, Kelly L, Milot D, Guo Q, Wang PR, Ippolito M, Chao YS, Wright SD, Thieringer R. Hermanowski-Vosatka A, et al. Among authors: wright sd. Biochem Biophys Res Commun. 2000 Dec 20;279(2):330-6. doi: 10.1006/bbrc.2000.3966. Biochem Biophys Res Commun. 2000. PMID: 11118287
A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux.
Sparrow CP, Baffic J, Lam MH, Lund EG, Adams AD, Fu X, Hayes N, Jones AB, Macnaul KL, Ondeyka J, Singh S, Wang J, Zhou G, Moller DE, Wright SD, Menke JG. Sparrow CP, et al. Among authors: wright sd. J Biol Chem. 2002 Mar 22;277(12):10021-7. doi: 10.1074/jbc.M108225200. Epub 2002 Jan 14. J Biol Chem. 2002. PMID: 11790770 Free article.
Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice.
Burton CA, Patel S, Mundt S, Hassing H, Zhang D, Hermanowski-Vosatka A, Wright SD, Chao YS, Detmers PA, Sparrow CP. Burton CA, et al. Among authors: wright sd. Biochem Biophys Res Commun. 2002 May 31;294(1):88-94. doi: 10.1016/S0006-291X(02)00441-2. Biochem Biophys Res Commun. 2002. PMID: 12054745
261 results