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The development of potent non-peptidic PTP-1B inhibitors.
Dufresne C, Roy P, Wang Z, Asante-Appiah E, Cromlish W, Boie Y, Forghani F, Desmarais S, Wang Q, Skorey K, Waddleton D, Ramachandran C, Kennedy BP, Xu L, Gordon R, Chan CC, Leblanc Y. Dufresne C, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1039-42. doi: 10.1016/j.bmcl.2003.11.048. Bioorg Med Chem Lett. 2004. PMID: 15013019
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
Asante-Appiah E, Patel S, Desponts C, Taylor JM, Lau C, Dufresne C, Therien M, Friesen R, Becker JW, Leblanc Y, Kennedy BP, Scapin G. Asante-Appiah E, et al. Among authors: dufresne c. J Biol Chem. 2006 Mar 24;281(12):8010-5. doi: 10.1074/jbc.M511827200. Epub 2006 Jan 6. J Biol Chem. 2006. PMID: 16407290 Free article.
Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.
Han Y, Belley M, Bayly CI, Colucci J, Dufresne C, Giroux A, Lau CK, Leblanc Y, McKay D, Therien M, Wilson MC, Skorey K, Chan CC, Scapin G, Kennedy BP. Han Y, et al. Among authors: dufresne c. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3200-5. doi: 10.1016/j.bmcl.2008.04.064. Epub 2008 Apr 29. Bioorg Med Chem Lett. 2008. PMID: 18477508
Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Leblanc Y, Roy P, Dufresne C, Lachance N, Wang Z, O'Neill G, Greig G, Denis D, Mathieu MC, Slipetz D, Sawyer N, Tsou N. Leblanc Y, et al. Among authors: dufresne c. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2125-8. doi: 10.1016/j.bmcl.2009.03.010. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19307115
The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.
Abramovitz M, Adam M, Boie Y, Carrière M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM. Abramovitz M, et al. Among authors: dufresne c. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. doi: 10.1016/s1388-1981(99)00164-x. Biochim Biophys Acta. 2000. PMID: 10634944
174 results