Jones PS - Search Results

1

Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic optimization of inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Barnes MC, Dowle MD, Hind SL, Johnson MR, Jones PS, Mills G, Patikis A, Pateman TJ, Redfern TJ, Robinson JE, Slater MJ, Trivedi N. Andrews DM, et al. Among authors: jones ps. Org Lett. 2003 Nov 27;5(24):4631-4. doi: 10.1021/ol035827n. Org Lett. 2003. PMID: 14627401

2

Pyrrolidine-5,5-trans-lactams. 1. Synthesis and incorporation into inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Carey SJ, Chaignot H, Coomber BA, Gray NM, Hind SL, Jones PS, Mills G, Robinson JE, Slater MJ. Andrews DM, et al. Among authors: jones ps. Org Lett. 2002 Dec 12;4(25):4475-8. doi: 10.1021/ol027013x. Org Lett. 2002. PMID: 12465916

3

Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents.

Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO. Andrews DM, et al. Among authors: jones ps. Org Lett. 2002 Dec 12;4(25):4479-82. doi: 10.1021/ol027014p. Org Lett. 2002. PMID: 12465917

4

Design and synthesis of spiro-cyclopentenyl and spiro-[1,3]-dithiolanyl substituted pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Jones PS, Mills G, Hind SL, Slater MJ, Trivedi N, Wareing KJ. Andrews DM, et al. Among authors: jones ps. Bioorg Med Chem Lett. 2003 May 19;13(10):1657-60. doi: 10.1016/s0960-894x(03)00274-9. Bioorg Med Chem Lett. 2003. PMID: 12729635

5

The design of potent, non-peptidic inhibitors of hepatitis C protease.

Andrews DM, Chaignot HM, Coomber BA, Dowle MD, Hind SL, Johnson MR, Jones PS, Mills G, Patikis A, Pateman TJ, Robinson JE, Slater MJ, Trivedi N. Andrews DM, et al. Among authors: jones ps. Eur J Med Chem. 2003 Apr;38(4):339-43. doi: 10.1016/s0223-5234(03)00050-3. Eur J Med Chem. 2003. PMID: 12750019

6

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.

Slater MJ, Amphlett EM, Andrews DM, Bamborough P, Carey SJ, Johnson MR, Jones PS, Mills G, Parry NR, Somers DO, Stewart AJ, Skarzynski T. Slater MJ, et al. Among authors: jones ps. Org Lett. 2003 Nov 27;5(24):4627-30. doi: 10.1021/ol035826v. Org Lett. 2003. PMID: 14627400

7

Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.

Slater MJ, Andrews DM, Baker G, Bethell SS, Carey S, Chaignot H, Clarke B, Coomber B, Ellis M, Good A, Gray N, Hardy G, Jones P, Mills G, Robinson E. Slater MJ, et al. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3359-62. doi: 10.1016/s0960-894x(02)00789-8. Bioorg Med Chem Lett. 2002. PMID: 12419361

8

Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR.

Mitchell CJ, Ballantine SP, Coe DM, Cook CM, Delves CJ, Dowle MD, Edlin CD, Hamblin JN, Holman S, Johnson MR, Jones PS, Keeling SE, Kranz M, Lindvall M, Lucas FS, Neu M, Solanke YE, Somers DO, Trivedi NA, Wiseman JO. Mitchell CJ, et al. Among authors: jones ps. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5803-6. doi: 10.1016/j.bmcl.2010.07.136. Epub 2010 Aug 5. Bioorg Med Chem Lett. 2010. PMID: 20732811

9

Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain.

Andrews DM, Cherry PC, Humber DC, Jones PS, Keeling SP, Martin PF, Shaw CD, Swanson S. Andrews DM, et al. Among authors: jones ps. Eur J Med Chem. 1999 Jul-Aug;34(7-8):563-74. doi: 10.1016/s0223-5234(00)80026-4. Eur J Med Chem. 1999. PMID: 11278042

10

The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.

Bennett JM, Campbell AD, Campbell AJ, Carr MG, Dunsdon RM, Greening JR, Hurst DN, Jennings NS, Jones PS, Jordan S, Kay PB, O'Brien MA, King-Underwood J, Raynham TM, Wilkinson CS, Wilkinson TC, Wilson FX. Bennett JM, et al. Among authors: jones ps. Bioorg Med Chem Lett. 2001 Feb 12;11(3):355-7. doi: 10.1016/s0960-894x(00)00654-5. Bioorg Med Chem Lett. 2001. PMID: 11212109

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