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The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI. Briscoe CP, et al. Among authors: andrews jl. J Biol Chem. 2003 Mar 28;278(13):11303-11. doi: 10.1074/jbc.M211495200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496284 Free article.
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S. Briscoe CP, et al. Among authors: andrews jl. Br J Pharmacol. 2006 Jul;148(5):619-28. doi: 10.1038/sj.bjp.0706770. Epub 2006 May 15. Br J Pharmacol. 2006. PMID: 16702987 Free PMC article.
144 results