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NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
Catley L, Weisberg E, Tai YT, Atadja P, Remiszewski S, Hideshima T, Mitsiades N, Shringarpure R, LeBlanc R, Chauhan D, Munshi NC, Schlossman R, Richardson P, Griffin J, Anderson KC. Catley L, et al. Among authors: shringarpure r. Blood. 2003 Oct 1;102(7):2615-22. doi: 10.1182/blood-2003-01-0233. Epub 2003 Jun 19. Blood. 2003. PMID: 12816865 Free article.
Immunomodulatory drug costimulates T cells via the B7-CD28 pathway.
LeBlanc R, Hideshima T, Catley LP, Shringarpure R, Burger R, Mitsiades N, Mitsiades C, Cheema P, Chauhan D, Richardson PG, Anderson KC, Munshi NC. LeBlanc R, et al. Among authors: shringarpure r. Blood. 2004 Mar 1;103(5):1787-90. doi: 10.1182/blood-2003-02-0361. Epub 2003 Sep 25. Blood. 2004. PMID: 14512311 Free article.
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Podar K, Catley LP, Tai YT, Shringarpure R, Carvalho P, Hayashi T, Burger R, Schlossman RL, Richardson PG, Pandite LN, Kumar R, Hideshima T, Chauhan D, Anderson KC. Podar K, et al. Among authors: shringarpure r. Blood. 2004 May 1;103(9):3474-9. doi: 10.1182/blood-2003-10-3527. Epub 2003 Nov 26. Blood. 2004. PMID: 14644994 Free article.
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications.
Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Hideshima T, Akiyama M, Chauhan D, Munshi N, Gu X, Bailey C, Joseph M, Libermann TA, Richon VM, Marks PA, Anderson KC. Mitsiades CS, et al. Among authors: shringarpure r. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):540-5. doi: 10.1073/pnas.2536759100. Epub 2003 Dec 26. Proc Natl Acad Sci U S A. 2004. PMID: 14695887 Free PMC article.
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Chauhan D, Li G, Podar K, Hideshima T, Shringarpure R, Catley L, Mitsiades C, Munshi N, Tai YT, Suh N, Gribble GW, Honda T, Schlossman R, Richardson P, Sporn MB, Anderson KC. Chauhan D, et al. Among authors: shringarpure r. Blood. 2004 Apr 15;103(8):3158-66. doi: 10.1182/blood-2003-08-2873. Epub 2003 Dec 11. Blood. 2004. PMID: 15070698 Free article.
Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells.
Tassone P, Goldmacher VS, Neri P, Gozzini A, Shammas MA, Whiteman KR, Hylander-Gans LL, Carrasco DR, Hideshima T, Shringarpure R, Shi J, Allam CK, Wijdenes J, Venuta S, Munshi NC, Anderson KC. Tassone P, et al. Among authors: shringarpure r. Blood. 2004 Dec 1;104(12):3688-96. doi: 10.1182/blood-2004-03-0963. Epub 2004 Aug 3. Blood. 2004. PMID: 15292058 Free article.
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Catley L, Tai YT, Shringarpure R, Burger R, Son MT, Podar K, Tassone P, Chauhan D, Hideshima T, Denis L, Richardson P, Munshi NC, Anderson KC. Catley L, et al. Among authors: shringarpure r. Cancer Res. 2004 Dec 1;64(23):8746-53. doi: 10.1158/0008-5472.CAN-04-2894. Cancer Res. 2004. PMID: 15574786
Antimyeloma activity of heat shock protein-90 inhibition.
Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Kung AL, Davies FE, Morgan G, Akiyama M, Shringarpure R, Munshi NC, Richardson PG, Hideshima T, Chauhan D, Gu X, Bailey C, Joseph M, Libermann TA, Rosen NS, Anderson KC. Mitsiades CS, et al. Among authors: shringarpure r. Blood. 2006 Feb 1;107(3):1092-100. doi: 10.1182/blood-2005-03-1158. Epub 2005 Oct 18. Blood. 2006. PMID: 16234364 Free PMC article.
51 results