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Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy.
Zoumpoulakis P, Zoga A, Roumelioti P, Giatas N, Grdadolnik SG, Iliodromitis E, Vlahakos D, Kremastinos D, Matsoukas JM, Mavromoustakos T. Zoumpoulakis P, et al. Among authors: kremastinos d. J Pharm Biomed Anal. 2003 Apr 1;31(5):833-44. doi: 10.1016/s0731-7085(02)00655-6. J Pharm Biomed Anal. 2003. PMID: 12684096
Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening.
Politi AP, Zervou MV, Triantafyllidi H, Zoumpoulakis PG, Mavromoustakos TM, Zoga AA, Moutevelis-Minakakis P, Kokotos G, Iliodromitis EK, Kremastinos DT. Politi AP, et al. J Renin Angiotensin Aldosterone Syst. 2010 Jun;11(2):103-10. doi: 10.1177/1470320310365016. Epub 2010 Mar 31. J Renin Angiotensin Aldosterone Syst. 2010. PMID: 20357048 Free article.
Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of pi*--pi* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT(1) non-peptide antagonists.
Polevaya L, Mavromoustakos T, Zoumboulakis P, Golic Grdadolnik S, Roumelioti P, Giatas N, Mutule I, Keivish T, Vlahakos DV, Iliodromitis EK, Kremastinos DT, Matsoukas J. Polevaya L, et al. Among authors: kremastinos dt. Bioorg Med Chem. 2001 Jun;9(6):1639-47. doi: 10.1016/s0968-0896(01)00059-1. Bioorg Med Chem. 2001. PMID: 11408184
479 results