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Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy.
J Pharm Biomed Anal. 2003 Apr 1;31(5):833-44. doi: 10.1016/s0731-7085(02)00655-6.
J Pharm Biomed Anal. 2003.
PMID: 12684096
Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges. Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists.
Roumelioti P, Polevaya L, Zoumpoulakis P, Giatas N, Mutule I, Keivish T, Zoga A, Vlahakos D, Iliodromitis E, Kremastinos D, Grdadolnik SG, Mavromoustakos T, Matsoukas J.
Roumelioti P, et al. Among authors: giatas n.
Bioorg Med Chem Lett. 2002 Sep 16;12(18):2627-33. doi: 10.1016/s0960-894x(02)00474-2.
Bioorg Med Chem Lett. 2002.
PMID: 12182875
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Conformation and bioactivity. Design and discovery of novel antihypertensive drugs.
Mavromoustakos T, Zervou M, Zoumpoulakis P, Kyrikou I, Benetis NP, Polevaya L, Roumelioti P, Giatas N, Zoga A, Minakakis PM, Kolocouris A, Vlahakos D, Grdadolnik SG, Matsoukas J.
Mavromoustakos T, et al. Among authors: giatas n.
Curr Top Med Chem. 2004;4(4):385-401. doi: 10.2174/1568026043451302.
Curr Top Med Chem. 2004.
PMID: 14965308
Review.
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Synthesis and study of a cyclic angiotensin II antagonist analogue reveals the role of pi*--pi* interactions in the C-terminal aromatic residue for agonist activity and its structure resemblance with AT(1) non-peptide antagonists.
Polevaya L, Mavromoustakos T, Zoumboulakis P, Golic Grdadolnik S, Roumelioti P, Giatas N, Mutule I, Keivish T, Vlahakos DV, Iliodromitis EK, Kremastinos DT, Matsoukas J.
Polevaya L, et al. Among authors: giatas n.
Bioorg Med Chem. 2001 Jun;9(6):1639-47. doi: 10.1016/s0968-0896(01)00059-1.
Bioorg Med Chem. 2001.
PMID: 11408184
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