Leysen D - Search Results

1

Structure-activity relationship study of human liver microsomes-catalyzed hydrolysis rate of ester prodrugs of MENT by comparative molecular field analysis (CoMFA).

Bursi R, Grootenhuis A, van der Louw J, Verhagen J, de Gooyer M, Jacobs P, Leysen D. Bursi R, et al. Among authors: leysen d. Steroids. 2003 Mar;68(3):213-20. doi: 10.1016/s0039-128x(02)00186-1. Steroids. 2003. PMID: 12628684

2

(Q) SAR study on the metabolic stability of steroidal androgens.

Bursi R, de Gooyer ME, Grootenhuis A, Jacobs PL, van der Louw J, Leysen D. Bursi R, et al. Among authors: leysen d. J Mol Graph Model. 2001;19(6):552-6, 607-8. doi: 10.1016/s1093-3263(01)00089-4. J Mol Graph Model. 2001. PMID: 11552683

3

Tibolone is not converted by human aromatase to 7alpha-methyl-17alpha-ethynylestradiol (7alpha-MEE): analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS.

de Gooyer ME, Oppers-Tiemissen HM, Leysen D, Verheul HA, Kloosterboer HJ. de Gooyer ME, et al. Among authors: leysen d. Steroids. 2003 Mar;68(3):235-43. doi: 10.1016/s0039-128x(02)00184-8. Steroids. 2003. PMID: 12628686

4

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

Roumen L, Peeters JW, Emmen JM, Beugels IP, Custers EM, de Gooyer M, Plate R, Pieterse K, Hilbers PA, Smits JF, Vekemans JA, Leysen D, Ottenheijm HC, Janssen HM, Hermans JJ. Roumen L, et al. Among authors: leysen d. J Med Chem. 2010 Feb 25;53(4):1712-25. doi: 10.1021/jm901356d. J Med Chem. 2010. PMID: 20121113

5

Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.

Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ. Roumen L, et al. Among authors: leysen d. J Comput Chem. 2011 Aug;32(11):2441-8. doi: 10.1002/jcc.21827. Epub 2011 May 19. J Comput Chem. 2011. PMID: 21598279

6

Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics.

Roumen L, Sanders MP, Pieterse K, Hilbers PA, Plate R, Custers E, de Gooyer M, Smits JF, Beugels I, Emmen J, Ottenheijm HC, Leysen D, Hermans JJ. Roumen L, et al. Among authors: leysen d. J Comput Aided Mol Des. 2007 Aug;21(8):455-71. doi: 10.1007/s10822-007-9128-9. Epub 2007 Jul 24. J Comput Aided Mol Des. 2007. PMID: 17646925 Free PMC article.

7

A comparison of the physicochemical and biological properties of mirtazapine and mianserin.

Kelder J, Funke C, De Boer T, Delbressine L, Leysen D, Nickolson V. Kelder J, et al. Among authors: leysen d. J Pharm Pharmacol. 1997 Apr;49(4):403-11. doi: 10.1111/j.2042-7158.1997.tb06814.x. J Pharm Pharmacol. 1997. PMID: 9232538

8

Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.

Boland S, Bourin A, Alen J, Geraets J, Schroeders P, Castermans K, Kindt N, Boumans N, Panitti L, Fransen S, Vanormelingen J, Stassen JM, Leysen D, Defert O. Boland S, et al. Among authors: leysen d. J Med Chem. 2015 May 28;58(10):4309-24. doi: 10.1021/acs.jmedchem.5b00308. Epub 2015 May 6. J Med Chem. 2015. PMID: 25898023

9

Prospects for improved antidepressants.

Broekkamp CL, Leysen D, Peeters BW, Pinder RM. Broekkamp CL, et al. Among authors: leysen d. J Med Chem. 1995 Nov 10;38(23):4615-33. doi: 10.1021/jm00023a001. J Med Chem. 1995. PMID: 7473589 Review. No abstract available.

10

Structure and serotonin 5-HT2C receptor activity of ortho- and meta-substituted phenylpiperazines.

Verdonk ML, Voogd JW, Kanters JA, Kroon J, den Besten R, Brandsma L, Leysen D, Kelder J. Verdonk ML, et al. Among authors: leysen d. Acta Crystallogr B. 1997 Dec 1;53 ( Pt 6):976-83. doi: 10.1107/s0108768197009142. Acta Crystallogr B. 1997. PMID: 9436302

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