Unitt J - Search Results

1

An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases.

Fowler A, Swift D, Longman E, Acornley A, Hemsley P, Murray D, Unitt J, Dale I, Sullivan E, Coldwell M. Fowler A, et al. Among authors: unitt j. Anal Biochem. 2002 Sep 15;308(2):223-31. doi: 10.1016/s0003-2697(02)00245-2. Anal Biochem. 2002. PMID: 12419333

2

A combinatorial biophysical approach; FTSA and SPR for identifying small molecule ligands and PAINs.

Redhead M, Satchell R, Morkūnaitė V, Swift D, Petrauskas V, Golding E, Onions S, Matulis D, Unitt J. Redhead M, et al. Among authors: unitt j. Anal Biochem. 2015 Jun 15;479:63-73. doi: 10.1016/j.ab.2015.03.013. Epub 2015 Mar 30. Anal Biochem. 2015. PMID: 25837771

3

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.

Kindon N, Andrews G, Baxter A, Cheshire D, Hemsley P, Johnson T, Liu YZ, McGinnity D, McHale M, Mete A, Reuberson J, Roberts B, Steele J, Teobald B, Unitt J, Vaughan D, Walters I, Stocks MJ. Kindon N, et al. Among authors: unitt j. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. doi: 10.1021/acsmedchemlett.7b00315. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947948 Free PMC article.

4

Dynamic analysis of STAT6 signalling in living cells.

Nelson G, Wilde GJ, Spiller DG, Sullivan E, Unitt JF, White MR. Nelson G, et al. Among authors: unitt jf. FEBS Lett. 2002 Dec 4;532(1-2):188-92. doi: 10.1016/s0014-5793(02)03672-4. FEBS Lett. 2002. PMID: 12459487 Free article.

5

NF-kappaB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms.

Nelson G, Wilde GJ, Spiller DG, Kennedy SM, Ray DW, Sullivan E, Unitt JF, White MR. Nelson G, et al. Among authors: unitt jf. J Cell Sci. 2003 Jun 15;116(Pt 12):2495-503. doi: 10.1242/jcs.00461. Epub 2003 May 6. J Cell Sci. 2003. PMID: 12734399

6

Multi-parameter analysis of the kinetics of NF-kappaB signalling and transcription in single living cells.

Nelson G, Paraoan L, Spiller DG, Wilde GJ, Browne MA, Djali PK, Unitt JF, Sullivan E, Floettmann E, White MR. Nelson G, et al. Among authors: unitt jf. J Cell Sci. 2002 Mar 15;115(Pt 6):1137-48. doi: 10.1242/jcs.115.6.1137. J Cell Sci. 2002. PMID: 11884514

7

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors.

Baxter A, Brough S, Cooper A, Floettmann E, Foster S, Harding C, Kettle J, McInally T, Martin C, Mobbs M, Needham M, Newham P, Paine S, St-Gallay S, Salter S, Unitt J, Xue Y. Baxter A, et al. Among authors: unitt j. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22. doi: 10.1016/j.bmcl.2004.03.058. Bioorg Med Chem Lett. 2004. PMID: 15125939

8

Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates.

Forbes LV, Sjögren T, Auchère F, Jenkins DW, Thong B, Laughton D, Hemsley P, Pairaudeau G, Turner R, Eriksson H, Unitt JF, Kettle AJ. Forbes LV, et al. Among authors: unitt jf. J Biol Chem. 2013 Dec 20;288(51):36636-47. doi: 10.1074/jbc.M113.507756. Epub 2013 Nov 5. J Biol Chem. 2013. PMID: 24194519 Free PMC article.

9

1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.

Hunt HJ, Belanoff JK, Golding E, Gourdet B, Phillips T, Swift D, Thomas J, Unitt JF, Walters I. Hunt HJ, et al. Among authors: unitt jf. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5720-5. doi: 10.1016/j.bmcl.2015.10.097. Epub 2015 Oct 31. Bioorg Med Chem Lett. 2015. PMID: 26546213

10

Development and validation of a simple cell-based fluorescence assay for dipeptidyl peptidase 1 (DPP1) activity.

Thong B, Pilling J, Ainscow E, Beri R, Unitt J. Thong B, et al. Among authors: unitt j. J Biomol Screen. 2011 Jan;16(1):36-43. doi: 10.1177/1087057110385228. Epub 2010 Nov 18. J Biomol Screen. 2011. PMID: 21088147

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