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Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.
Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J, Phillips T, Swift D, Eaton E. Hunt HJ, et al. Among authors: swift d. J Med Chem. 2017 Apr 27;60(8):3405-3421. doi: 10.1021/acs.jmedchem.7b00162. Epub 2017 Apr 17. J Med Chem. 2017. PMID: 28368581
Key aspects of modern GPCR drug discovery.
Addis P, Bali U, Baron F, Campbell A, Harborne S, Jagger L, Milne G, Pearce M, Rosethorne EM, Satchell R, Swift D, Young B, Unitt JF. Addis P, et al. Among authors: swift d. SLAS Discov. 2024 Jan;29(1):1-22. doi: 10.1016/j.slasd.2023.08.007. Epub 2023 Aug 23. SLAS Discov. 2024. PMID: 37625784 Free article. Review.
A National audit of the care of patients with acute kidney injury in England and Wales in 2019 and the association with patient outcomes.
Graham-Brown MPM, Casula A, Savino M, Humphrey T, Pyart R, Amaran M, Williams J, Crowe K, Medcalf JF; NEPHwork consortium collaborators. All involved in data collection and or local project setup and supervision. Graham-Brown MPM, et al. Clin Med (Lond). 2024 Mar;24(2):100028. doi: 10.1016/j.clinme.2024.100028. Epub 2024 Feb 20. Clin Med (Lond). 2024. PMID: 38387536 Free PMC article.
Time-resolved X-ray diffraction diagnostic development for the National Ignition Facility.
Werellapatha K, Palmer NE, Gorman MG, Bernier JV, Bhandarkar NS, Bradley DK, Braun DG, Bruhn M, Carpenter A, Celliers PM, Coppari F, Dayton M, Durand C, Eggert JH, Ferguson B, Heidl B, Heinbockel C, Heredia R, Huckins J, Hurd E, Hsing W, Krauland CM, Lazicki AE, Kalantar D, Kehl J, Killebrew K, Masters N, Millot M, Nagel SR, Petre RB, Ping Y, Polsin DN, Singh S, Stan CV, Swift D, Tabimina J, Thomas A, Zobrist T, Benedetti LR. Werellapatha K, et al. Among authors: swift d. Rev Sci Instrum. 2024 Jan 1;95(1):013903. doi: 10.1063/5.0161343. Rev Sci Instrum. 2024. PMID: 38236087
309 results