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Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
Bioorg Med Chem. 2002 Sep;10(9):2941-52. doi: 10.1016/s0968-0896(02)00157-8.
Bioorg Med Chem. 2002.
PMID: 12110316
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
Kupchinsky S, Centioni S, Howard T, Trzupek J, Roller S, Carnahan V, Townes H, Purnell B, Price C, Handl H, Summerville K, Johnson K, Toth J, Hudson S, Kiakos K, Hartley JA, Lee M.
Kupchinsky S, et al.
Bioorg Med Chem. 2004 Dec 1;12(23):6221-36. doi: 10.1016/j.bmc.2004.08.051.
Bioorg Med Chem. 2004.
PMID: 15519165
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Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7-trimethoxyindole-2-carboxamide (iso-CFI) analogs of duocarmycin C2: synthesis and biological evaluation.
Purnell B, Lingerfelt B, Scott A, Townes H, Summerville K, Hudson S, Kiakos K, Hartley JA, Lee M.
Purnell B, et al.
Med Chem. 2006 Mar;2(2):139-46. doi: 10.2174/157340606776056188.
Med Chem. 2006.
PMID: 16787363
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DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
Purnell B, Sato A, O'kelley A, Price C, Summerville K, Hudson S, O'hare C, Kiakos K, Asao T, Lee M, Hartley JA.
Purnell B, et al.
Bioorg Med Chem Lett. 2006 Nov 1;16(21):5677-81. doi: 10.1016/j.bmcl.2006.08.005. Epub 2006 Aug 21.
Bioorg Med Chem Lett. 2006.
PMID: 16919946
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(S,S)-trans-cyclopentane-constrained peptide nucleic acids. a general backbone modification that improves binding affinity and sequence specificity.
Pokorski JK, Witschi MA, Purnell BL, Appella DH.
Pokorski JK, et al. Among authors: purnell bl.
J Am Chem Soc. 2004 Nov 24;126(46):15067-73. doi: 10.1021/ja046280q.
J Am Chem Soc. 2004.
PMID: 15548003
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