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Synthesis and antitrypanosomal evaluation of E-isomers of 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives. structure-activity relationships.
Cerecetto H, Di Maio R, González M, Risso M, Sagrera G, Seoane G, Denicola A, Peluffo G, Quijano C, Stoppani AO, Paulino M, Olea-Azar C, Basombrío MA. Cerecetto H, et al. Among authors: denicola a. Eur J Med Chem. 2000 Mar;35(3):343-50. doi: 10.1016/s0223-5234(00)00131-8. Eur J Med Chem. 2000. PMID: 10785560
Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design.
Aguirre G, Cabrera E, Cerecetto H, Di Maio R, González M, Seoane G, Duffaut A, Denicola A, Gil MJ, Martínez-Merino V. Aguirre G, et al. Among authors: denicola a. Eur J Med Chem. 2004 May;39(5):421-31. doi: 10.1016/j.ejmech.2004.02.007. Eur J Med Chem. 2004. PMID: 15110968
Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds.
Aguirre G, Boiani L, Cerecetto H, Di Maio R, González M, Porcal W, Denicola A, Möller M, Thomson L, Tórtora V. Aguirre G, et al. Among authors: denicola a. Bioorg Med Chem. 2005 Dec 1;13(23):6324-35. doi: 10.1016/j.bmc.2005.05.020. Epub 2005 Aug 22. Bioorg Med Chem. 2005. PMID: 16115774
117 results