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Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart.
Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF, Kaya Z, Yusung SA, Davis SE, Frisancho JA, Barrett MA, Rose NR. Fairweather D, et al. Among authors: rose nr. J Immunol. 2006 Mar 15;176(6):3516-24. doi: 10.4049/jimmunol.176.6.3516. J Immunol. 2006. PMID: 16517720
Cardiomyopathy is linked to complement activation.
Afanasyeva M, Rose NR. Afanasyeva M, et al. Among authors: rose nr. Am J Pathol. 2002 Aug;161(2):351-7. doi: 10.1016/S0002-9440(10)64189-2. Am J Pathol. 2002. PMID: 12163358 Free PMC article. No abstract available.
585 results