Chhajlani V - Search Results

1

3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists.

Semple G, Andersson BM, Chhajlani V, Georgsson J, Johansson M, Lindschoten M, Pontén F, Rosenquist A, Sörensen H, Swanson L, Swanson M. Semple G, et al. Among authors: chhajlani v. Bioorg Med Chem Lett. 2002 Jan 21;12(2):197-200. doi: 10.1016/s0960-894x(01)00691-6. Bioorg Med Chem Lett. 2002. PMID: 11755353

2

Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods.

Semple G, Andersson BM, Chhajlani V, Georgsson J, Johansson MJ, Rosenquist A, Swanson L. Semple G, et al. Among authors: chhajlani v. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1141-5. doi: 10.1016/s0960-894x(03)00033-7. Bioorg Med Chem Lett. 2003. PMID: 12643930

3

4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.

Xiong H, Brugel TA, Balestra M, Brown DG, Brush KA, Hightower C, Hinkley L, Hoesch V, Kang J, Koether GM, McCauley JP Jr, McLaren FM, Panko LM, Simpson TR, Smith RW, Woods JM, Brockel B, Chhajlani V, Gadient RA, Spear N, Sygowski LA, Zhang M, Arora J, Breysse N, Wilson JM, Isaac M, Slassi A, King MM. Xiong H, et al. Among authors: chhajlani v. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7381-4. doi: 10.1016/j.bmcl.2010.10.036. Epub 2010 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 21067920

4

Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268.

Zysk JR, Widzowski D, Sygowski LA, Knappenberger KS, Spear N, Elmore CS, Dorff P, Liu H, Doherty J, Chhajlani V. Zysk JR, et al. Among authors: chhajlani v. Synapse. 2011 Jan;65(1):64-8. doi: 10.1002/syn.20817. Synapse. 2011. PMID: 20506301

5

Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist.

Frändberg PA, Doufexis M, Kapas S, Chhajlani V. Frändberg PA, et al. Among authors: chhajlani v. Biochem Biophys Res Commun. 2001 Mar 9;281(4):851-7. doi: 10.1006/bbrc.2001.4429. Biochem Biophys Res Commun. 2001. PMID: 11237737

6

In vitro binding of a radio-labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5.

Zysk JR, Spear N, Fieles W, Stein MM, Sygowski LS, King MM, Hoesch V, Hastings R, Brockel B, Do M, Ström P, Gadient R, Chhajlani V, Elmore CS, Maier DL. Zysk JR, et al. Among authors: chhajlani v. Synapse. 2013 Mar;67(3):135-44. doi: 10.1002/syn.21625. Epub 2012 Dec 6. Synapse. 2013. PMID: 23150216

7

Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.

Chhajlani V, Rangel N, Uhlén S, Wikberg JE. Chhajlani V, et al. FEBS Lett. 1991 Mar 25;280(2):241-4. doi: 10.1016/0014-5793(91)80301-i. FEBS Lett. 1991. PMID: 1849485 Free article.

8

[³H]Chiba-1001(methyl-SSR180711) has low in vitro binding affinity and poor in vivo selectivity to nicotinic alpha-7 receptor in rodent brain.

Ding M, Ghanekar S, Elmore CS, Zysk JR, Werkheiser JL, Lee CM, Liu J, Chhajlani V, Maier DL. Ding M, et al. Among authors: chhajlani v. Synapse. 2012 Apr;66(4):315-22. doi: 10.1002/syn.21513. Epub 2011 Dec 29. Synapse. 2012. PMID: 22108786

9

Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator.

Spear N, Gadient RA, Wilkins DE, Do M, Smith JS, Zeller KL, Schroeder P, Zhang M, Arora J, Chhajlani V. Spear N, et al. Among authors: chhajlani v. Eur J Pharmacol. 2011 Jun 1;659(2-3):146-54. doi: 10.1016/j.ejphar.2011.02.003. Epub 2011 Feb 16. Eur J Pharmacol. 2011. PMID: 21335002

10

Acute pharmacological modulation of mGluR8 reduces measures of anxiety.

Duvoisin RM, Pfankuch T, Wilson JM, Grabell J, Chhajlani V, Brown DG, Johnson E, Raber J. Duvoisin RM, et al. Among authors: chhajlani v. Behav Brain Res. 2010 Oct 15;212(2):168-73. doi: 10.1016/j.bbr.2010.04.006. Epub 2010 Apr 10. Behav Brain Res. 2010. PMID: 20385173 Free PMC article.

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