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Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI).
ACS Med Chem Lett. 2018 Dec 3;10(1):86-91. doi: 10.1021/acsmedchemlett.8b00462. eCollection 2019 Jan 10.
ACS Med Chem Lett. 2018.
PMID: 30655952
Free PMC article.
Discovery of TD-4306, a long-acting β2-agonist for the treatment of asthma and COPD.
McKinnell RM, Klein U, Linsell MS, Moran EJ, Nodwell MB, Pfeiffer JW, Thomas GR, Yu C, Jacobsen JR.
McKinnell RM, et al.
Bioorg Med Chem Lett. 2014 Jul 1;24(13):2871-6. doi: 10.1016/j.bmcl.2014.04.095. Epub 2014 May 4.
Bioorg Med Chem Lett. 2014.
PMID: 24835980
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Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties.
McKinnell RM, Armstrong SR, Beattie DT, Fatheree PR, Long DD, Marquess DG, Shaw JP, Vickery RG.
McKinnell RM, et al.
Bioorg Med Chem Lett. 2013 Jul 15;23(14):4210-5. doi: 10.1016/j.bmcl.2013.05.018. Epub 2013 May 16.
Bioorg Med Chem Lett. 2013.
PMID: 23756062
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A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.
McKinnell RM, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum A, Humphrey PP, Long DD, Marquess DG, Shaw JP, Smith JA, Turner SD, Vickery RG.
McKinnell RM, et al.
J Med Chem. 2009 Sep 10;52(17):5330-43. doi: 10.1021/jm900881j.
J Med Chem. 2009.
PMID: 19663444
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Tris(trifluoromethanesulfonyl)methide ("Triflide") Anion: Convenient Preparation, X-ray Crystal Structures, and Exceptional Catalytic Activity as a Counterion with Ytterbium(III) and Scandium(III).
Waller FJ, Barrett AG, Braddock DC, Ramprasad D, McKinnell RM, White AJ, Williams DJ, Ducray R.
Waller FJ, et al. Among authors: mckinnell rm.
J Org Chem. 1999 Apr 16;64(8):2910-2913. doi: 10.1021/jo9800917.
J Org Chem. 1999.
PMID: 11674365
No abstract available.
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