Markwalder JA - Search Results

1

Identification of selective inhibitors of cyclin dependent kinase 4.

Carini DJ, Kaltenbach RF, Liu J, Benfield PA, Boylan J, Boisclair M, Brizuela L, Burton CR, Cox S, Grafstrom R, Harrison BA, Harrison K, Akamike E, Markwalder JA, Nakano Y, Seitz SP, Sharp DM, Trainor GL, Sielecki TM. Carini DJ, et al. Among authors: markwalder ja. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2209-11. doi: 10.1016/s0960-894x(01)00416-4. Bioorg Med Chem Lett. 2001. PMID: 11514172

2

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

Lam PY, Ru Y, Jadhav PK, Aldrich PE, DeLucca GV, Eyermann CJ, Chang CH, Emmett G, Holler ER, Daneker WF, Li L, Confalone PN, McHugh RJ, Han Q, Li R, Markwalder JA, Seitz SP, Sharpe TR, Bacheler LT, Rayner MM, Klabe RM, Shum L, Winslow DL, Kornhauser DM, Hodge CN, et al. Lam PY, et al. Among authors: markwalder ja. J Med Chem. 1996 Aug 30;39(18):3514-25. doi: 10.1021/jm9602571. J Med Chem. 1996. PMID: 8784449

3

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.

Patel M, Ko SS, McHugh RJ Jr, Markwalder JA, Srivastava AS, Cordova BC, Klabe RM, Erickson-Viitanen S, Trainor GL, Seitz SP. Patel M, et al. Among authors: markwalder ja. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2805-10. doi: 10.1016/s0960-894x(99)00486-2. Bioorg Med Chem Lett. 1999. PMID: 10522695

4

Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz.

Mutlib AE, Chen H, Nemeth GA, Markwalder JA, Seitz SP, Gan LS, Christ DD. Mutlib AE, et al. Among authors: markwalder ja. Drug Metab Dispos. 1999 Nov;27(11):1319-33. Drug Metab Dispos. 1999. PMID: 10534318

5

The species-dependent metabolism of efavirenz produces a nephrotoxic glutathione conjugate in rats.

Mutlib AE, Gerson RJ, Meunier PC, Haley PJ, Chen H, Gan LS, Davies MH, Gemzik B, Christ DD, Krahn DF, Markwalder JA, Seitz SP, Robertson RT, Miwa GT. Mutlib AE, et al. Among authors: markwalder ja. Toxicol Appl Pharmacol. 2000 Nov 15;169(1):102-13. doi: 10.1006/taap.2000.9055. Toxicol Appl Pharmacol. 2000. PMID: 11076702

6

3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors.

Corbett JW, Pan S, Markwalder JA, Cordova BC, Klabe RM, Garber S, Rodgers JD, Erickson-Viitanen SK. Corbett JW, et al. Among authors: markwalder ja. Bioorg Med Chem Lett. 2001 Jan 22;11(2):211-4. doi: 10.1016/s0960-894x(00)00624-7. Bioorg Med Chem Lett. 2001. PMID: 11206461

7

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.

Markwalder JA, Christ DD, Mutlib A, Cordova BC, Klabe RM, Seitz SP. Markwalder JA, et al. Bioorg Med Chem Lett. 2001 Mar 12;11(5):619-22. doi: 10.1016/s0960-894x(01)00012-9. Bioorg Med Chem Lett. 2001. PMID: 11266155

8

A kinetic characterization of the glycosyltransferase activity of Eschericia coli PBP1b and development of a continuous fluorescence assay.

Schwartz B, Markwalder JA, Seitz SP, Wang Y, Stein RL. Schwartz B, et al. Among authors: markwalder ja. Biochemistry. 2002 Oct 15;41(41):12552-61. doi: 10.1021/bi026205x. Biochemistry. 2002. PMID: 12369847

9

Regulated expression of the Escherichia coli lepB gene as a tool for cellular testing of antimicrobial compounds that inhibit signal peptidase I in vitro.

Barbosa MD, Lin S, Markwalder JA, Mills JA, DeVito JA, Teleha CA, Garlapati V, Liu C, Thompson A, Trainor GL, Kurilla MG, Pompliano DL. Barbosa MD, et al. Among authors: markwalder ja. Antimicrob Agents Chemother. 2002 Nov;46(11):3549-54. doi: 10.1128/AAC.46.11.3549-3554.2002. Antimicrob Agents Chemother. 2002. PMID: 12384363 Free PMC article.

10

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.

Yue EW, DiMeo SV, Higley CA, Markwalder JA, Burton CR, Benfield PA, Grafstrom RH, Cox S, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Trainor GL, Seitz SP. Yue EW, et al. Among authors: markwalder ja. Bioorg Med Chem Lett. 2004 Jan 19;14(2):343-6. doi: 10.1016/j.bmcl.2003.11.008. Bioorg Med Chem Lett. 2004. PMID: 14698155

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