McGuire R - Search Results

1

The first potent and selective inhibitors of the glycine transporter type 2.

Caulfield WL, Collie IT, Dickins RS, Epemolu O, McGuire R, Hill DR, McVey G, Morphy JR, Rankovic Z, Sundaram H. Caulfield WL, et al. Among authors: mcguire r. J Med Chem. 2001 Aug 16;44(17):2679-82. doi: 10.1021/jm0011272. J Med Chem. 2001. PMID: 11495577 No abstract available.

2

Non-depolarizing neuromuscular blocking activity of bisquaternary amino di- and tripeptide derivatives.

Booij LH, van der Broek LA, Caulfield W, Dommerholt-Caris BM, Clark JK, van Egmond J, McGuire R, Muir AW, Ottenheijm HC, Rees DC. Booij LH, et al. Among authors: mcguire r. J Med Chem. 2000 Dec 14;43(25):4822-33. doi: 10.1021/jm0010062. J Med Chem. 2000. PMID: 11123992

3

Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors.

Anderson A, Belelli D, Bennett DJ, Buchanan KI, Casula A, Cooke A, Feilden H, Gemmell DK, Hamilton NM, Hutchinson EJ, Lambert JJ, Maidment MS, McGuire R, McPhail P, Miller S, Muntoni A, Peters JA, Sansbury FH, Stevenson D, Sundaram H. Anderson A, et al. Among authors: mcguire r. J Med Chem. 2001 Oct 25;44(22):3582-91. doi: 10.1021/jm010903i. J Med Chem. 2001. PMID: 11606122

4

Design and synthesis of a maximally diverse and druglike screening library using REM resin methodology.

Barn D, Caulfield W, Cowley P, Dickins R, Bakker WI, McGuire R, Morphy JR, Rankovic Z, Thorn M. Barn D, et al. Among authors: mcguire r. J Comb Chem. 2001 Nov-Dec;3(6):534-41. doi: 10.1021/cc000096t. J Comb Chem. 2001. PMID: 11703148

5

Conformationally constrained anesthetic steroids that modulate GABA(A) receptors.

Anderson A, Boyd AC, Clark JK, Fielding L, Gemmell DK, Hamilton NM, Maidment MS, May V, McGuire R, McPhail P, Sansbury FH, Sundaram H, Taylor R. Anderson A, et al. Among authors: mcguire r. J Med Chem. 2000 Nov 2;43(22):4118-25. doi: 10.1021/jm000977e. J Med Chem. 2000. PMID: 11063608

6

Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments.

Gibson S, McGuire R, Rees DC. Gibson S, et al. Among authors: mcguire r. J Med Chem. 1996 Sep 27;39(20):4065-72. doi: 10.1021/jm960058h. J Med Chem. 1996. PMID: 8831772

7

Derivation and validation of toxicophores for mutagenicity prediction.

Kazius J, McGuire R, Bursi R. Kazius J, et al. Among authors: mcguire r. J Med Chem. 2005 Jan 13;48(1):312-20. doi: 10.1021/jm040835a. J Med Chem. 2005. PMID: 15634026

8

Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6.

Janssen FJ, Deng H, Baggelaar MP, Allarà M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R, Di Marzo V, Overkleeft HS, van der Stelt M. Janssen FJ, et al. Among authors: mcguire r. J Med Chem. 2014 Aug 14;57(15):6610-22. doi: 10.1021/jm500681z. Epub 2014 Jul 23. J Med Chem. 2014. PMID: 24988361

9

A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design.

Sanders MP, Roumen L, van der Horst E, Lane JR, Vischer HF, van Offenbeek J, de Vries H, Verhoeven S, Chow KY, Verkaar F, Beukers MW, McGuire R, Leurs R, Ijzerman AP, de Vlieg J, de Esch IJ, Zaman GJ, Klomp JP, Bender A, de Graaf C. Sanders MP, et al. Among authors: mcguire r. J Med Chem. 2012 Jun 14;55(11):5311-25. doi: 10.1021/jm300280e. Epub 2012 May 23. J Med Chem. 2012. PMID: 22563707

10

X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.

Fradera X, Vu D, Nimz O, Skene R, Hosfield D, Wynands R, Cooke AJ, Haunsø A, King A, Bennett DJ, McGuire R, Uitdehaag JC. Fradera X, et al. Among authors: mcguire r. J Mol Biol. 2010 May 28;399(1):120-32. doi: 10.1016/j.jmb.2010.04.005. Epub 2010 Apr 9. J Mol Biol. 2010. PMID: 20382159

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