Hiramatsu Y - Search Results

1

Studies on selectin blocker. 9. SARs of non-sugar selectin blocker against E-, P-, L-selectin bindings.

Moriyama H, Hiramatsu Y, Kiyoi T, Achiha T, Inoue Y, Kondo H. Moriyama H, et al. Among authors: hiramatsu y. Bioorg Med Chem. 2001 Jun;9(6):1479-91. doi: 10.1016/s0968-0896(01)00023-2. Bioorg Med Chem. 2001. PMID: 11408166

As a part of study of selectin blockers, we have already reported that a non-sugar selectin antagonist (3) was successfully discovered using a computational screening (Hiramatsu, Y.; Tsukida, T.; Nakai, Y.; Inoue, Y.; Kondo, H. J. Med. ...

As a part of study of selectin blockers, we have already reported that a non-sugar selectin antagonist (3) was successfully discovered using …

2

Studies on selectin blockers. 4. Structure-function relationships of sulfated sialyl Lewis X hexasaccharide ceramides toward E-, P-, and L-selectin binding.

Yoshino K, Ohmoto H, Kondo N, Tsujishita H, Hiramatsu Y, Inoue Y, Kondo H. Yoshino K, et al. Among authors: hiramatsu y. J Med Chem. 1997 Feb 14;40(4):455-62. doi: 10.1021/jm9605290. J Med Chem. 1997. PMID: 9046335

3

Studies on selection blockers. 5. Design, synthesis, and biological profile of sialyl Lewis x mimetics based on modified serine-glutamic acid dipeptides.

Tsukida T, Hiramatsu Y, Tsujishita H, Kiyoi T, Yoshida M, Kurokawa K, Moriyama H, Ohmoto H, Wada Y, Saito T, Kondo H. Tsukida T, et al. Among authors: hiramatsu y. J Med Chem. 1997 Oct 24;40(22):3534-41. doi: 10.1021/jm970262k. J Med Chem. 1997. PMID: 9357520

4

Studies on selectin blockers. 6. Discovery of homologous fucose sugar unit necessary for E-selectin binding.

Hiramatsu Y, Moriyama H, Kiyoi T, Tsukida T, Inoue Y, Kondo H. Hiramatsu Y, et al. J Med Chem. 1998 Jun 18;41(13):2302-7. doi: 10.1021/jm9707481. J Med Chem. 1998. PMID: 9632363

5

Study on selectin blocker. 8. Lead discovery of a non-sugar antagonist using a 3D-pharmacophore model.

Hiramatsu Y, Tsukida T, Nakai Y, Inoue Y, Kondo H. Hiramatsu Y, et al. J Med Chem. 2000 Apr 20;43(8):1476-83. doi: 10.1021/jm990342j. J Med Chem. 2000. PMID: 10780903

In a series of sugar mimetic studies of the E-selectin ligand, sialyl Lewis X (sLe(x)), we have already found a potent compound, a sulfated Le(x) analogue (1), and also have proposed how compound 1 binds to E-selectin (Tsujishita, H.; Hiramatsu, Y.; Kondo, N.; Ohmot …

In a series of sugar mimetic studies of the E-selectin ligand, sialyl Lewis X (sLe(x)), we have already found a potent compound, a sulfated …

6

Studies on selectin blocker. 3. Investigation of the carbohydrate ligand sialyl Lewis X recognition site of P-selectin.

Hiramatsu Y, Tsujishita H, Kondo H. Hiramatsu Y, et al. J Med Chem. 1996 Nov 8;39(23):4547-53. doi: 10.1021/jm960134g. J Med Chem. 1996. PMID: 8917642

7

Selectin-ligand interactions revealed by molecular dynamics simulation in solution.

Tsujishita H, Hiramatsu Y, Kondo N, Ohmoto H, Kondo H, Kiso M, Hasegawa A. Tsujishita H, et al. Among authors: hiramatsu y. J Med Chem. 1997 Jan 31;40(3):362-9. doi: 10.1021/jm9606103. J Med Chem. 1997. PMID: 9022803

8

A three-dimensional quantitative structure-activity relationship study of heparin-binding epidermal growth factor shedding inhibitors using comparative molecular field analysis.

Bursi R, Sawa M, Hiramatsu Y, Kondo H. Bursi R, et al. Among authors: hiramatsu y. J Med Chem. 2002 Feb 14;45(4):781-8. doi: 10.1021/jm0110385. J Med Chem. 2002. PMID: 11831891

9

Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: orally active, potent, and selective prostaglandin D2 receptor antagonists.

Tsuri T, Honma T, Hiramatsu Y, Okada T, Hashizume H, Mitsumori S, Inagaki M, Arimura A, Yasui K, Asanuma F, Kishino J, Ohtani M. Tsuri T, et al. Among authors: hiramatsu y. J Med Chem. 1997 Oct 24;40(22):3504-7. doi: 10.1021/jm970343g. J Med Chem. 1997. PMID: 9357516 No abstract available.

10

Development changes of polyamine biosynthesis in rat liver.

Eguchi K, Yonezawa M, Ohmoto H, Mitsui Y, Hiramatsu Y. Eguchi K, et al. Among authors: hiramatsu y. Biol Neonate. 1992;62(6):402-8. doi: 10.1159/000243898. Biol Neonate. 1992. PMID: 1472582

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