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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Sapkota GP, et al. Among authors: lain s. J Biol Chem. 2001 Jun 1;276(22):19469-82. doi: 10.1074/jbc.M009953200. Epub 2001 Jan 31. J Biol Chem. 2001. PMID: 11297520 Free article.
Sirtuins and p53.
van Leeuwen I, Lain S. van Leeuwen I, et al. Among authors: lain s. Adv Cancer Res. 2009;102:171-95. doi: 10.1016/S0065-230X(09)02005-3. Adv Cancer Res. 2009. PMID: 19595309 Review.
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
Ladds MJGW, Popova G, Pastor-Fernández A, Kannan S, van Leeuwen IMM, Håkansson M, Walse B, Tholander F, Bhatia R, Verma CS, Lane DP, Laín S. Ladds MJGW, et al. Among authors: lain s. J Biol Chem. 2020 Dec 25;295(52):17935-17949. doi: 10.1074/jbc.RA119.012056. Epub 2020 Sep 8. J Biol Chem. 2020. PMID: 32900849 Free PMC article.
Activation of p53 in cervical carcinoma cells by small molecules.
Hietanen S, Lain S, Krausz E, Blattner C, Lane DP. Hietanen S, et al. Among authors: lain s. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8501-6. doi: 10.1073/pnas.97.15.8501. Proc Natl Acad Sci U S A. 2000. PMID: 10900010 Free PMC article.
150 results