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Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere.
Mimoto T, Hattori N, Takaku H, Kisanuki S, Fukazawa T, Terashima K, Kato R, Nojima S, Misawa S, Ueno T, Imai J, Enomoto H, Tanaka S, Sakikawa H, Shintani M, Hayashi H, Kiso Y. Mimoto T, et al. Among authors: shintani m. Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1310-26. doi: 10.1248/cpb.48.1310. Chem Pharm Bull (Tokyo). 2000. PMID: 10993230
Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic.
Mimoto T, Imai J, Tanaka S, Hattori N, Takahashi O, Kisanuki S, Nagano Y, Shintani M, Hayashi H, Sakikawa H, et al. Mimoto T, et al. Among authors: shintani m. Chem Pharm Bull (Tokyo). 1991 Sep;39(9):2465-7. doi: 10.1248/cpb.39.2465. Chem Pharm Bull (Tokyo). 1991. PMID: 1804562
[Clinical application of HIV protease inhibitors].
Chiba N, Shintani M, Ueno T, Hayashi H. Chiba N, et al. Among authors: shintani m. Tanpakushitsu Kakusan Koso. 1998 May;43(6):744-51. Tanpakushitsu Kakusan Koso. 1998. PMID: 9612068 Review. Japanese. No abstract available.
JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1.
Yoshimura K, Kato R, Yusa K, Kavlick MF, Maroun V, Nguyen A, Mimoto T, Ueno T, Shintani M, Falloon J, Masur H, Hayashi H, Erickson J, Mitsuya H. Yoshimura K, et al. Among authors: shintani m. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8675-80. doi: 10.1073/pnas.96.15.8675. Proc Natl Acad Sci U S A. 1999. PMID: 10411934 Free PMC article.
A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection.
Humphrey RW, Wyvill KM, Nguyen BY, Shay LE, Kohler DR, Steinberg SM, Ueno T, Fukasawa T, Shintani M, Hayashi H, Mitsuya H, Yarchoan R. Humphrey RW, et al. Among authors: shintani m. Antiviral Res. 1999 Feb;41(1):21-33. doi: 10.1016/s0166-3542(98)00058-8. Antiviral Res. 1999. PMID: 10321576 Clinical Trial.
246 results