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Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere.
Mimoto T, Hattori N, Takaku H, Kisanuki S, Fukazawa T, Terashima K, Kato R, Nojima S, Misawa S, Ueno T, Imai J, Enomoto H, Tanaka S, Sakikawa H, Shintani M, Hayashi H, Kiso Y. Mimoto T, et al. Among authors: fukazawa t. Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1310-26. doi: 10.1248/cpb.48.1310. Chem Pharm Bull (Tokyo). 2000. PMID: 10993230
KNI-577, a potent small-sized HIV protease inhibitor based on the dipeptide containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic.
Kiso Y, Yamaguchi S, Matsumoto H, Mimoto T, Kato R, Nojima S, Takaku H, Fukazawa T, Kimura T, Akaji K. Kiso Y, et al. Among authors: fukazawa t. Arch Pharm (Weinheim). 1998 Mar;331(3):87-9. doi: 10.1002/(sici)1521-4184(199803)331:3<87::aid-ardp87>3.0.co;2-h. Arch Pharm (Weinheim). 1998. PMID: 9557134 No abstract available.
Removal of human immunodeficiency virus type 1 (HIV-1) protease inhibitors from preparations of immature HIV-1 virions does not result in an increase in infectivity or the appearance of mature morphology.
Humphrey RW, Ohagen A, Davis DA, Fukazawa T, Hayashi H, Höglund S, Mitsuya H, Yarchoan R. Humphrey RW, et al. Among authors: fukazawa t. Antimicrob Agents Chemother. 1997 May;41(5):1017-23. doi: 10.1128/AAC.41.5.1017. Antimicrob Agents Chemother. 1997. PMID: 9145862 Free PMC article.
[Psychiatric vocational rehabilitation and therapy].
Ueno T, Daiguji N, Fukazawa T. Ueno T, et al. Among authors: fukazawa t. Seishin Shinkeigaku Zasshi. 1990;92(11):773-8. Seishin Shinkeigaku Zasshi. 1990. PMID: 2087526 Japanese. No abstract available.
(3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Nitta A, Fujii H, Sakami S, Nishimura Y, Ohyama T, Satoh M, Nakaki J, Satoh S, Inada C, Kozono H, Kumagai H, Shimamura M, Fukazawa T, Kawai H. Nitta A, et al. Among authors: fukazawa t. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5435-8. doi: 10.1016/j.bmcl.2008.09.042. Epub 2008 Sep 12. Bioorg Med Chem Lett. 2008. PMID: 18819797
416 results