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The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion.
Cicatiello L, Addeo R, Altucci L, Belsito Petrizzi V, Boccia V, Cancemi M, Germano D, Pacilio C, Salzano S, Bresciani F, Weisz A. Cicatiello L, et al. Mol Cell Endocrinol. 2000 Jul 25;165(1-2):199-209. doi: 10.1016/s0303-7207(00)00243-4. Mol Cell Endocrinol. 2000. PMID: 10940498
Distinct signaling pathways mediate stimulation of cell cycle progression and prevention of apoptotic cell death by estrogen in rat pituitary tumor PR1 cells.
Caporali S, Imai M, Altucci L, Cancemi M, Caristi S, Cicatiello L, Matarese F, Penta R, Sarkar DK, Bresciani F, Weisz A. Caporali S, et al. Among authors: cicatiello l. Mol Biol Cell. 2003 Dec;14(12):5051-9. doi: 10.1091/mbc.e03-05-0303. Epub 2003 Sep 5. Mol Biol Cell. 2003. PMID: 12960425 Free PMC article.
Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter.
Cicatiello L, Addeo R, Sasso A, Altucci L, Petrizzi VB, Borgo R, Cancemi M, Caporali S, Caristi S, Scafoglio C, Teti D, Bresciani F, Perillo B, Weisz A. Cicatiello L, et al. Mol Cell Biol. 2004 Aug;24(16):7260-74. doi: 10.1128/MCB.24.16.7260-7274.2004. Mol Cell Biol. 2004. PMID: 15282324 Free PMC article.
38 results