Increased karyotype precision using fluorescence in situ hybridization and spectral karyotyping in patients with myeloid malignancies

Cancer Genet Cytogenet. 1999 Jan 15;108(2):166-70. doi: 10.1016/s0165-4608(98)00137-x.

Abstract

We studied seven patients with various malignant hematologic disorders using fluorescence in situ hybridization (FISH) and one of these patients with spectral karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16) were confirmed in two patients and the karyotypic precision was increased in five others using FISH and SKY. Two of three patients with 12p rearrangements had a deletion of one TEL allele. Thus, these newer techniques are an important adjunct to accurate chromosome analysis in malignancy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Chromosome Banding
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence / standards*
  • Karyotyping / methods*
  • Leukemia, Myeloid / genetics*
  • Male
  • Middle Aged