Abstract
Cytogenetic analysis of a malignant sacrococcygeal teratoma in an adult patient revealed near-haploid (77%), near-diploid (19%), and polyploid (4%) cells. The near-haploid cells had a karyotype of 25,XX,der(5)t(5;7)(p15;p13),+7,der(9)t(6;9)(p21;q34),r(17)(p13q25) . In the near-diploid and polyploid cells identical copies of the structural chromosomal changes were found. Although some of the anomalies observed appear unique to this case, a common breakpoint in chromosome 6 was previously reported as specific in a subgroup of extragonadal germ cell tumors of adults.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Chromosome Mapping
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Chromosomes, Human, Pair 5
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Chromosomes, Human, Pair 6
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Chromosomes, Human, Pair 7
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Chromosomes, Human, Pair 9
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Coccyx
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Diploidy
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Fatal Outcome
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Female
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Haploidy
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Humans
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Karyotyping
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Ploidies*
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Polyploidy
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Sacrum
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Spinal Neoplasms / diagnostic imaging
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Spinal Neoplasms / genetics*
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Spinal Neoplasms / pathology
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Spinal Neoplasms / therapy
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Teratoma / diagnostic imaging
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Teratoma / genetics*
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Teratoma / pathology
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Teratoma / therapy
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Tomography, X-Ray Computed
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Translocation, Genetic