Abstract
Two patients with chronic myelogenous leukemia are described in whom thrombotic thrombocytopenic purpura (TTP) developed following treatment by interferon-alpha. In one of the patients, a lymphoblastic transformation was diagnosed concomitantly. Prompt institution of plasmapheresis, steroids and vincristine resulted in complete resolution. In the hitherto reported case of TTP complicating interferon-alpha treated chronic myelogenous leukemia, the course was fatal.
MeSH terms
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Female
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Humans
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Interferon-alpha / adverse effects*
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Interferon-alpha / therapeutic use
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
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Middle Aged
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Purpura, Thrombotic Thrombocytopenic / etiology*
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Purpura, Thrombotic Thrombocytopenic / therapy
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Treatment Outcome
Substances
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Antineoplastic Agents
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Interferon-alpha